{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:38:32Z","timestamp":1774125512091,"version":"3.50.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Objective:<\/i> Psychosocial stress has been suggested as a possible aggravating factor in liver diseases, however, the underlying mechanism has yet to be clarified. Recently, our research revealed that electric foot-shock stress aggravated NK1.1 Ag<sup>+<\/sup> T cell-dependent \u03b1-galactosylceramide (\u03b1-GalCer)-induced hepatitis in mice via a mechanism mediated by endogenous glucocorticoids. In this study, we examined whether or not such aggravation could be applied to a <i>psychosocially<\/i> stressful situation, e.g. social disruption stress. <i>Methods:<\/i> Male wild-type C57BL\/6 (B6) or B6 hepatitis virus type B surface antigen transgenic (HBs-tg) mice, a hepatitis B virus carrier mouse model, were exposed 3 times in 1 week to social disruption stress in which an 8-month-old aggressive male intruder was placed into their home cage (5 mice per group) for 2 h. Twelve hours after the final exposure to the stress, the wild-type and HBs-tg mice were intravenously injected with \u03b1-GalCer. <i>Results:<\/i> The stress-exposed wild-type mice exhibited significantly reduced thymus weight loss compared with the control animals. Moreover, this stress regimen led to a significant increase in serum alanine aminotransferase levels in both the wild-type and the HBs-tg mice, although the increase in the HBs-tg mice was higher than that in the wild-type mice. <i>Conclusion:<\/i> These findings demonstrated that, similar to electric foot-shock stress, social disruption stress exacerbated \u03b1-GalCer-induced hepatitis.<\/jats:p>","DOI":"10.1159\/000091131","type":"journal-article","created":{"date-parts":[[2006,3,24]],"date-time":"2006-03-24T09:46:49Z","timestamp":1143193609000},"page":"375-379","source":"Crossref","is-referenced-by-count":5,"title":["Social Disruption Stress Exacerbates \u03b1-Galactosylceramide-Induced Hepatitis in Mice"],"prefix":"10.1159","volume":"12","author":[{"given":"Junko","family":"Sonoda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Chida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Sudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiharu","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3999%2889%2990013-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.psy.45.2.100"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.20158"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000080153"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.lfs.2004.08.032"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.278.5343.1626"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2F1521-4141%28200007%2930%3A7%3C1919%3A%3AAID-IMMU1919%3E3.0.CO%3B2-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.510290605"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.97.15.8461"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.192.7.921"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.191.1.105"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291521-4141%28199811%2928%3A11%3C3448%3A%3AAID-IMMU3448%3E3.0.CO%3B2-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000119008"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0031-9384%2899%2900072-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-4530%2899%2900066-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2899%2900005-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0031-9384%2889%2990107-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2897%2900186-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0024-3205%2801%2901106-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-4530%2802%2900117-8"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.47.6.861"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1037%2F0022-006X.70.3.739"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.84.19.6909"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2889%2990770-8"}],"container-title":["Neuroimmunomodulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:51:33Z","timestamp":1745463093000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000091131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2006,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000091131","archive":["Portico"],"relation":{},"ISSN":["1021-7401","1423-0216"],"issn-type":[{"value":"1021-7401","type":"print"},{"value":"1423-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}