{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:01:11Z","timestamp":1769576471974,"version":"3.49.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>The involvement of matrix metalloproteinases (MMPs) in ischemic-stroke-induced inflammatory response has recently been suggested; however, the relationship between MMPs and stroke progression has not been evaluated. We investigated the role of MMPs in neurological worsening of acute lacunar infarction. Forty-nine consecutive patients with an acute lacunar infarction (as defined by clinical and MRI criteria within 48 h after stroke onset) were evaluated. Clinical, biochemical, rheological, inflammatory and other parameters were compared between progressive and nonprogressive groups. Among the variables, only inflammatory parameters, including MMP-9 and erythrocyte sedimentation rate, were associated with neurological worsening of acute lacunar infarction (p &lt; 0.05). These results suggest that the inflammatory process could play an important role in early neurological worsening of acute lacunar infarction.<\/jats:p>","DOI":"10.1159\/000091137","type":"journal-article","created":{"date-parts":[[2006,1,26]],"date-time":"2006-01-26T07:56:02Z","timestamp":1138262162000},"page":"11-15","source":"Crossref","is-referenced-by-count":35,"title":["The Role of Matrix Metalloproteinase 9 in Early Neurological Worsening of Acute Lacunar Infarction"],"prefix":"10.1159","volume":"55","author":[{"given":"Young Seo","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu-Yong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Ho","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Yun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Joo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Tae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung-Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Suk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-il","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2803%2900352-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161%2Fhs0402.105339"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000077012"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.57.2.255"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tox.2005.06.023"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-510X%2802%2900160-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000108169"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2894%2992757-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000057976.53301.69"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.62.3.393"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000016924.55448.43"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000108270"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1460-9568.2004.03632.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrn1106"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fglia.10108"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-199811000-00001"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000046764.57344.31"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161%2Fhs1201.99512"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000088062.86084.F2"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:51:36Z","timestamp":1745463096000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000091137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000091137","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}