{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:40:38Z","timestamp":1761986438419,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Mastocytosis is associated with a pathological increase in tissue mast cells. Associated skeletal problems include a decrease in bone density and pathological fractures. &lt;i&gt;Methods:&lt;\/i&gt; In order to explore the relationship between bone density and the severity of mastocytosis, 21 patients with mastocytosis who underwent dual-energy X-ray absorptiometry were entered into this study. Correlation coefficients were computed between Z-scores and demographic, clinical and laboratory data. Femoral neck Z-scores correlated with serum tryptase levels when all the patients were considered (p = 0.029). &lt;i&gt;Results and Conclusion:&lt;\/i&gt; Patients with less severe disease had significantly lower values at the L1\u2013L4 spine (p = 0.046) and femoral neck (p = 0.029) Z-scores compared to patients with more severe disease. Most patients who had low Z-scores (between \u20131 and \u20132.5) were under 50 years of age, had less severe disease and had lower serum tryptase levels. A history of gastroesophageal reflux disease and a history of hypotensive episodes correlated with lower L1\u2013L4 spine Z-scores (p &lt; 0.05). Thus, patients with less severe disease and lower serum tryptase levels should in particular have their bone density determined with treatment appropriate to the findings.<\/jats:p>","DOI":"10.1159\/000091172","type":"journal-article","created":{"date-parts":[[2006,2,2]],"date-time":"2006-02-02T11:02:32Z","timestamp":1138878152000},"page":"265-270","source":"Crossref","is-referenced-by-count":33,"title":["Elevated Tryptase Levels Are Associated with Greater Bone Density in a Cohort of Patients with Mastocytosis"],"prefix":"10.1159","volume":"139","author":[{"given":"Nataliya M.","family":"Kushnir-Sukhov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Brittain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Akin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean D.","family":"Metcalfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,2,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.med.55.091902.103822"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000048184"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00663015"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Frheumatology%2F35.9.898"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00002517-199109000-00016"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002560050350"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.285.6.785"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2908761-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fjbmr.5650050811"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F8756-3282%2889%2990059-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fageing%2F25.1.1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001980050224"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1191%2F0961203303lu1036oa"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00054725-200405000-00007"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.2003.016253"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:51:45Z","timestamp":1745463105000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000091172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000091172","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2006]]}}}