{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:20:51Z","timestamp":1781551251503,"version":"3.54.5"},"reference-count":7,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Although Jr&lt;sup&gt;a&lt;\/sup&gt; hemolytic disease of the newborn (HDN) is generally considered to be mild, we encountered a case of anti-Jr&lt;sup&gt;a&lt;\/sup&gt; alloimmunization hydrops fetalis due to extremely severe fetal anemia that required aggressive intrauterine treatment. &lt;i&gt;Case Report:&lt;\/i&gt; A Japanese woman developed hydrops fetalis at the 29th week of gestation. Blood examination was highly positive for anti-Jr&lt;sup&gt;a&lt;\/sup&gt; antibodies. Cordocentesis demonstrated that the fetus had anti-Jr&lt;sup&gt;a&lt;\/sup&gt; antibodies and the lowest fetal hemoglobin concentration was 2.3 g\/dl. After a total of four intravascular transfusions, fetal hydrops improved and a healthy girl of 2,120 g was delivered at the 35th week of gestation. The initial neonatal hemoglobin concentration at birth was 7.2 g\/dl. After two straight transfusions, the infant\u2019s anemia did not worsen. Anti-Jr&lt;sup&gt;a&lt;\/sup&gt; antibodies became negative without developing hyperbilirubinemia. &lt;i&gt;Conclusion:&lt;\/i&gt; The incidence of Jr&lt;sup&gt;a&lt;\/sup&gt; negativity can lead to underestimation of the risk of Jr&lt;sup&gt;a&lt;\/sup&gt; alloimmunization. This case shows that anti-Jr&lt;sup&gt;a&lt;\/sup&gt; alloimmunization may cause HDN and hydrops fetalis.<\/jats:p>","DOI":"10.1159\/000091354","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T11:51:50Z","timestamp":1144237910000},"page":"269-271","source":"Crossref","is-referenced-by-count":25,"title":["Successful Treatment of Extremely Severe Fetal Anemia due to Anti-Jr&lt;sup&gt;a&lt;\/sup&gt; Alloimmunization"],"prefix":"10.1159","volume":"21","author":[{"given":"Yuki","family":"Ishihara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,4,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1423-0410.1978.tb02932.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1423-0410.1981.tb01010.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1537-2995.1978.18579036387.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1620%2Ftjem.145.97"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2801%2901724-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1537-2995.2004.00643.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000073145"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:53:27Z","timestamp":1745463207000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000091354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":7,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2006,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000091354","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}