{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:37:45Z","timestamp":1791959865045,"version":"4.3.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Background\/Aims:<\/i> Attempting to improve the cerebrospinal fluid (CSF) diagnosis of Alzheimer\u2019s disease (AD), the neurofilament heavy chain isoform, NfH<sup>SMI35<\/sup> was compared to other CSF markers [total tau, phospho-tau, amyloid beta 1\u201342 (A\u03b242), the ratio of amyloid beta fragments A\u03b242\/A\u03b240 (A\u03b2 ratio)]. <i>Methods:<\/i> CSF levels were determined in patients with AD (n = 109), mild cognitive impairment (MCI, n = 25), frontotemporal dementia (n = 15), vascular dementia (VD, n = 41), and controls (n = 58). <i>Results:<\/i> CSF NfH<sup>SMI35<\/sup> was elevated in AD and VD as compared to controls (p < 0.05). Total tau was higher in AD as compared to controls (p < 0.05). CSF phospho-tau was elevated in AD as compared to controls and VD (p < 0.05 each). CSF A\u03b242 and A\u03b2 ratios in AD were lower than in MCI and controls (p < 0.05 each). <i>Conclusion:<\/i> The diagnostic potential of NfH<sup>SMI35<\/sup> is not superior to that of other CSF markers.<\/jats:p>","DOI":"10.1159\/000091436","type":"journal-article","created":{"date-parts":[[2006,2,13]],"date-time":"2006-02-13T09:25:00Z","timestamp":1139822700000},"page":"291-295","source":"Crossref","is-referenced-by-count":55,"title":["The Neurofilament Heavy Chain (NfH<sup>SMI35<\/sup>) in the Cerebrospinal Fluid Diagnosis of Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"21","author":[{"given":"Johannes","family":"Brettschneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Petzold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sch\u00f6ttle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annett","family":"Claus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Riepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrettin","family":"Tumani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,5,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004010050418"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1385%2FMN%3A24%3A1-3%3A087"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2803%2900086-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.64.3.298"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20477"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410380413"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410440108"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.70.5.624"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-1759%2803%2900189-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2003.017236"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fjnr.1242"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.56.3.303"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.10157"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000080967"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109%2F13506120009146438"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.1993.tb09823.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2800%2901036-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%281950%293%3A1%3C32%3A%3AAID-CNCR2820030106%3E3.0.CO%3B2-3"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2897%2900215-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.59.8.1267"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-510X%2898%2900122-1"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91436","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:54:27Z","timestamp":1745463267000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000091436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":22,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2006,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000091436","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}