{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:53:42Z","timestamp":1771044822787,"version":"3.50.1"},"reference-count":9,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Background:<\/i> Slowing of inspiratory muscle relaxation has been used as an index for inspiratory muscle fatigue. However, maximum relaxation rate measured from oesophageal pressure traces after maximum sniff (P<sub>oes<\/sub> MRR) has limited clinical usefulness because it requires an oesophageal balloon catheter system. <i>Objectives:<\/i> It was the aim of this study to establish whether, in neuromuscular patients, maximum relaxation rate assessed from sniff nasal pressure (P<sub>nasal<\/sub> MRR) reflects oesophageal MRR and the tension-time index of the diaphragm (TT<sub>di<\/sub>). <i>Methods:<\/i> Twenty patients with neuromuscular disease and 10 healthy subjects were studied. P<sub>oes<\/sub> and transdiaphragmatic pressure were measured while P<sub>nasal<\/sub> was recorded with a balloon advanced through the nose into the nasopharynx. Maximum P<sub>oes<\/sub>, transdiaphragmatic pressure and P<sub>nasal<\/sub> were simultaneously measured while the patients performed maximal sniffs. The MRR (% pressure fall\/10 ms) for each sniff, the TT<sub>di<\/sub> and the tension-time index of respiratory muscles were determined. <i>Results:<\/i> Neuromuscular patients showed higher TT<sub>di<\/sub>, lower P<sub>oes<\/sub> MRR and lower P<sub>nasal<\/sub> MRR than the control group. In patients with neuromuscular disease, the correlation coefficient of P<sub>nasal<\/sub> MRR and P<sub>oes<\/sub> MRR was 0.985 (p < 0.001). Regression analysis showed that P<sub>oes<\/sub> MRR = \u20131.101 + 1.113\u00b7P<sub>nasal<\/sub> MRR (r<sup>2<\/sup> = 0.929, standard error of the estimate = 0.208). Indeed, P<sub>nasal<\/sub> MRR was negatively correlated with TT<sub>di<\/sub> (r = \u20130.914, p < 0.001) and the tension-time index of respiratory muscles (r = \u20130.732, p < 0.001). In the neuromuscular group, the mean difference between P<sub>nasal<\/sub> MRR and P<sub>oes<\/sub> MRR was 0.286 \u00b1 0.217%\/10 ms. <i>Conclusions:<\/i> P<sub>nasal<\/sub> MRR obtained from a maximal sniff accurately reflects P<sub>oes<\/sub> MRR and TT<sub>di<\/sub> in patients with neuromuscular disorders.<\/jats:p>","DOI":"10.1159\/000091804","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T10:07:28Z","timestamp":1141207648000},"page":"474-480","source":"Crossref","is-referenced-by-count":5,"title":["Noninvasive Measurement of the Maximum Relaxation Rate of Inspiratory Muscles in Patients with Neuromuscular Disorders"],"prefix":"10.1159","volume":"73","author":[{"given":"F.","family":"Garc\u00eda-R\u00edo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Mediano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Pino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Lores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.","family":"Alvarez-Sala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Villamor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,7,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.49.11.1127"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.49.7.703"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.110.2.446"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1063%2F1.330569"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.120.3.765"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.293.6554.1055"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.97.10061292"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fthorax.57.3.254"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.110.2.454"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91804","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:58:26Z","timestamp":1745463506000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000091804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000091804","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}