{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T22:42:04Z","timestamp":1772577724427,"version":"3.50.1"},"reference-count":9,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Low- and high-dose dexamethasone suppression tests (LDDST, HDDST) are used in the investigation of Cushing\u2019s syndrome (CS). In adults with Cushing\u2019s disease (CD), cortisol suppression during LDDST predicts suppression during the HDDST. &lt;i&gt;Methods:&lt;\/i&gt; We reviewed the results of the LDDST (0.5 mg 6 hourly \u00d7 48 h), HDDST (2.0 mg 6 hourly \u00d7 48 h) and corticotrophin-releasing hormone (CRH) test in 32 paediatric patients with CS: 24 had CD, 1 ectopic ACTH syndrome, 5 nodular adrenal hyperplasia and 2 adrenocortical tumours. &lt;i&gt;Results:&lt;\/i&gt; In CD, LDDST suppressed cortisol from 590.7 \u00b1 168.8 (mean \u00b1 SD) to 333.7 \u00b1 104.0 nmol\/l after 48 h (0 vs. 48 h, p &lt; 0.05; mean suppression, 45.1%; CI (30.8, 59.4%); 16\/24 (66%) suppressed &gt;30%; mean suppression 68.1%, CI (58.1, 77.9%)). The HDDST suppressed cortisol from 596.3 \u00b1 174.5 to 47.1 \u00b1 94.8 nmol\/l after 48 h (0 vs. 48 h, p &lt; 0.05; mean suppression, 93.5%; CI (88.2, 98.8%) with 17\/24 (71%) suppressing to &lt;50 nmol\/l and 100% to &lt;50% of baseline). In the LDDST, suppression correlated with that during the HDDST (r = +0.45, p &lt; 0.05) with &gt;30% suppression predicting that in the HDDST and hence CD. CRH increased cortisol by +100.3% (CI 62, 138.5%), 22\/24 (91.7%) showing a &gt;20% increase. In the other CS pathologies (n = 8) the LDDST induced no significant decrease in cortisol. &lt;i&gt;Conclusion:&lt;\/i&gt; The LDDST was of diagnostic value by discriminating between CD and other CS aetiologies. In our view the HDDST is redundant in the investigation of paediatric CS.<\/jats:p>","DOI":"10.1159\/000091830","type":"journal-article","created":{"date-parts":[[2006,3,3]],"date-time":"2006-03-03T09:34:49Z","timestamp":1141378489000},"page":"159-162","source":"Crossref","is-referenced-by-count":15,"title":["The Discriminatory Value of the Low-Dose Dexamethasone Suppression Test in the Investigation of Paediatric Cushing\u2019s Syndrome"],"prefix":"10.1159","volume":"65","author":[{"given":"R.","family":"Dias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.L.","family":"Storr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.A.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Isidori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.B.","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.O.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,3,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.19.5.647"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F1043-2760%2896%2900089-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-030510"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.12.5711"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.1.01921"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199409083311002"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1227%2F01.NEU.0000166580.94215.53"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-021032"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2004.02124.x"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/91830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:58:39Z","timestamp":1745463519000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000091830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2006,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000091830","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}