{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:36:49Z","timestamp":1792276609358,"version":"4.4.0"},"reference-count":34,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Peri-intraventricular hemorrhage (P\/IVH) is a common neonatal morbidity among premature infants. The aim of the study was to examine the association between placental and\/or fetal inflammation and the onset of P\/IVH in premature infants. &lt;i&gt;Methods:&lt;\/i&gt; A prospective study included 125 infants with gestational age 23\u201329 weeks. Placentas were examined for the presence of chorioamnionitis and funisitis, cord blood was sampled for the measurement of cytokines (IL-6 and IL-8). Fetal inflammation was defined as levels of IL-6 higher than 7.6 pg\/ml. P\/IVH was defined as early if diagnosed within the 1st day after birth; thereafter P\/IVH was defined as late. &lt;i&gt;Results:&lt;\/i&gt; Adjusted for the influence of gestational age, early-onset sepsis (OR 3.2, p = 0.045) and no or incomplete antenatal steroid course (OR 6.0, p = 0.001) significantly predicted early P\/IVH. Funisitis (OR 1.6, p = 0.06) and fetal inflammation (OR 2.6, p = 0.06) were only partially associated with early hemorrhage. Contrary to that, respiratory distress syndrome (OR 3.4, p = 0.04), mechanical ventilation (OR 5.9, p = 0.008), low blood pressure (OR 3.5, p = 0.02), and vasopressors (OR 5.7, p = 0.002) were associated with late P\/IVH. In multivariate analysis no or incomplete steroid course remained independent predictors for early and use of vasopressors for late P\/IVH. The interaction of fetal inflammation and vaginal delivery with no or incomplete steroid course increased the risk of early P\/IVH. &lt;i&gt;Conclusions:&lt;\/i&gt; These results indicate different risk factors for early and late P\/IVH. Neither funisitis nor fetal inflammation independently predicts the onset of P\/IVH. However, the interaction of fetal inflammation and vaginal delivery with no or incomplete antenatal steroid course increase the risk of early but not also late P\/IVH.<\/jats:p>","DOI":"10.1159\/000092070","type":"journal-article","created":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T07:59:00Z","timestamp":1142582340000},"page":"113-121","source":"Crossref","is-referenced-by-count":34,"title":["Intrauterine Inflammation and the Onset of Peri-Intraventricular Hemorrhage in Premature Infants"],"prefix":"10.1159","volume":"90","author":[{"given":"Janez","family":"Babnik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Stucin-Gantar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilijana","family":"Kornhauser-Cerar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasna","family":"Sinkovec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branka","family":"Wraber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metka","family":"Derganc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,8,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0095-5108%2802%2900048-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0028-2243%2890%2990094-H"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-3782%2895%2901651-I"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2007-994514"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9378%2895%2990001-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.112.1.33"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS1071-5576%2801%2900101-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS1071-5576%2803%2900150-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053%2Fplac.1999.0499"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080%2F713605804"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000068924"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Ffn.88.6.F501"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2805%2982056-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-3782%2889%2990120-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2878%2980282-0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.82.3.188"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000088071.30873.DA"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.1982.57.2.0219"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1017%2FS0012162201001724"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.111.5.e590"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jp.7210612"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198307283090402"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1067%2FS0002-9378%2803%2900758-0"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000115681.95957.D4"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1750-3639.2000.tb00248.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1080%2F713605445"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000148713.48218.86"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1053%2Fsiny.2001.0065"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2800%2900928-5"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2004.06.055"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1067%2FS0022-3476%2803%2900417-7"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000120678.72485.19"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1159%2F000047130"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2000.109035"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:01:14Z","timestamp":1745463674000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000092070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000092070","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}