{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:01:40Z","timestamp":1787950900656,"version":"build-2784847793"},"reference-count":14,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Magnetic resonance imaging provides a noninvasive method to study the fate of transplanted cells in vivo. &lt;i&gt;Objective:&lt;\/i&gt; We studied the fate of embryonic and mesenchymal stem cells labeled with iron oxide nanoparticles (Endorem&lt;sup&gt;\u00ae&lt;\/sup&gt;) and human CD34+ cells labeled with magnetic MicroBeads (Miltenyi) in rats with a cortical or spinal cord lesion. &lt;i&gt;Methods:&lt;\/i&gt; Cells were grafted intracerebrally, contralaterally to a cortical photochemical lesion, or injected intravenously. &lt;i&gt;Results:&lt;\/i&gt; During the 1st week after transplantation, transplanted cells migrated to the lesion and were visible in the lesion on MR images as a hypointensive signal, persisting for more than 30 days. In rats with a balloon-induced spinal cord compression lesion, we observed an increase in functional recovery and hind limb sensitivity after implantation of Endorem-labeled mesenchymal stem cells or a freshly prepared mononuclear fraction of bone marrow cells or after injection of granulocyte colony-stimulating factor. Morphometric measurements in the center of the lesions showed an increase in white matter volume in cell-treated animals. Prussian blue staining confirmed a large number of Prussian blue-positive cells, and the lesions were considerably smaller than in control animals. &lt;i&gt;Conclusions:&lt;\/i&gt; These studies demonstrate that magnetic resonance imaging of grafted adult as well as embryonic stem cells labeled with iron oxide nanoparticles is a useful method for evaluating their migration and fate in CNS.<\/jats:p>","DOI":"10.1159\/000092095","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T13:49:21Z","timestamp":1148651361000},"page":"62-67","source":"Crossref","is-referenced-by-count":66,"title":["Magnetic Resonance Tracking of Transplanted Stem Cells in Rat Brain and Spinal Cord"],"prefix":"10.1159","volume":"3","author":[{"given":"Eva","family":"Sykov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavla","family":"Jendelov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2892%2991135-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fmrm.1910330209"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS1076-6332%2898%2980084-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.96.26.15256"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fnbt1201-1141"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS1053-8119%2802%2991194-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fmrm.10585"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fjnr.20041"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1196%2Fannals.1334.014"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.284.5411.143"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0361-9230%2897%2900463-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1162%2F153535004773861697"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fmrm.1910250115"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3727%2F000000005783983124"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:01:29Z","timestamp":1745463689000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000092095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":14,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2006,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000092095","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}