{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:01:41Z","timestamp":1789790501693,"version":"4.0.1"},"reference-count":28,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Aim:&lt;\/i&gt; The purpose of this study was to develop an accurate regression model to predict insulin resistance in girls with premature adrenarche. &lt;i&gt;Methods:&lt;\/i&gt; The insulin sensitivity index was calculated from the frequently sampled intravenous glucose tolerance test with tolbutamide. Thirty-five prepubertal girls (23 Caribbean-Hispanic and 12 African-American; mean age 6.8 years) were studied. The insulin sensitivity index was compared to birth weight, body mass index (BMI), the presence of acanthosis nigricans (AN), insulin-like growth factor 1, insulin-like growth factor binding protein 1, sex hormone binding globulin, lipid profile, and adrenocorticotropic hormone stimulated androgens. &lt;i&gt;Results:&lt;\/i&gt; The best prediction models included birth weight, BMI, and AN (model 1: R&lt;sup&gt;2&lt;\/sup&gt; = 0.78) and BMI, AN, and serum 17-OH pregnenolone (model 2: R&lt;sup&gt;2&lt;\/sup&gt; = 0.76). When viewed as screening tests, a cutoff value &lt;5.5 (premature adrenarche insulin resistance score) in both equations showed a sensitivity of 100% and a specificity of 85%. &lt;i&gt;Conclusion:&lt;\/i&gt; Born small for gestational age, premature adrenarche, obesity, AN, and higher serum 17-OH pregnenolone levels may confer negative, but independent, health risks.<\/jats:p>","DOI":"10.1159\/000092103","type":"journal-article","created":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T07:59:00Z","timestamp":1142582340000},"page":"185-191","source":"Crossref","is-referenced-by-count":2,"title":["Prediction Models for Insulin Resistance in Girls with Premature Adrenarche"],"prefix":"10.1159","volume":"65","author":[{"given":"Patricia","family":"Vuguin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Grinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Saenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"DiMartino Nardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.74.2.236"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.6.2037"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.10.3558"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1999.tb14406.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fedrv-6-1-45"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.10.4618"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000057945"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.10.4615"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-64-3-609"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2898%2970433-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-70-6-1644"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiacare.27.5.1148"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.46.7.1167"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177%2F0272989X9101100205"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2894%2970128-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-73-3-674"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.102.3.e36"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199211053271904"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.80.1.172"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2000.105141"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiacare.25.10.1887"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.80.2.614"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2001.112657"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00399954"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00400248"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199703000-00023"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2002.124312"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291520-6300%281999%2911%3A2%3C249%3A%3AAID-AJHB12%3E3.0.CO%3B2-%23"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:01:33Z","timestamp":1745463693000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000092103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000092103","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}