{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:40:06Z","timestamp":1745466006970,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Although many arguments have been raised on the role of heredity in the etiology of acne, the relevant genetic elements in the pathogenesis of the disease are not well established. &lt;i&gt;Objective:&lt;\/i&gt; The aim of our study was to evaluate the association between a genetic polymorphism in the promoter region of the CYP17 gene and the development of acne. &lt;i&gt;Methods:&lt;\/i&gt; 206 acne patients and 200 controls were included in the study. A polymerase chain reaction (PCR) sequencing technique was used to reveal a CYP17 gene polymorphism in its promoter region. A \u03c7&lt;sup&gt;2&lt;\/sup&gt; test was used for data analysis. &lt;i&gt;Results:&lt;\/i&gt; CYP17 \u201334T\/C polymorphism was found and the frequency distribution of the C\/C homozygotes and C allele in the male patients with severe acne (33.3 and 60.9%, respectively) were statistically significantly different from those of the control samples (18.2 and 46.6%; p &lt; 0.05). No significant difference was observed between the female patients, mild + moderate male patients and their controls, respectively. &lt;i&gt;Conclusion:&lt;\/i&gt; The CYP17 \u201334C\/C homozygote Chinese men are at a significantly increased risk of developing severe acne.<\/jats:p>","DOI":"10.1159\/000092284","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T13:49:21Z","timestamp":1148651361000},"page":"338-342","source":"Crossref","is-referenced-by-count":25,"title":["The Relationship between CYP17 \u201334T\/C Polymorphism and Acne in Chinese Subjects Revealed by Sequencing"],"prefix":"10.1159","volume":"212","author":[{"given":"Li","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoweng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenru","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongli","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunjie","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,5,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2898%2970442-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0906-6705.2005.0285a.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000051771"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2000.03669.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.285.6346.912"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1089%2Fdna.1987.6.439"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F3.10.1873"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0215%2820000801%2987%3A3%3C434%3A%3AAID-IJC19%3E3.0.CO%3B2-G"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00008571-199910000-00010"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2820010901%2992%3A5%3C1130%3A%3AAID-CNCR1430%3E3.0.CO%3B2-B"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2808%2980076-X"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2003.618"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1432-1033.1973.tb02881.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000067819"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2002.19621.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1999.02979.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000017855"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.1998.3811205.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1986.tb04880.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0039-128X%2896%2900171-7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.3529394"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159%2F000081484"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:02:39Z","timestamp":1745463759000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000092284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000092284","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2006]]}}}