{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:58:57Z","timestamp":1778176737799,"version":"3.51.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Introduction:<\/i> It has been suggested that <i>Helicobacter pylori<\/i> eradication often increases platelet counts in patients with chronic idiopathic thrombocytopenic purpura (ITP). In addition, <i>H. pylori <\/i>has been shown to induce platelet activation (CD62p or P-selectin expression) in previous studies. We assessed the response of platelet count and CD62p expression after eradication therapy in patients with ITP and <i>H. pylori<\/i> infection. <i>Methods and Results:<\/i> We prospectively studied 15 ITP patients diagnosed with <i>H. pylori<\/i> infection by serology and breath test. A follow-up breath test was used to document eradication. Two out of 15 patients showed improvement in platelet counts after 6 months, 1 of which may have had drug-induced thrombocytopenia. Overall, certain platelet response rate in our series was 6.7% (1\/15). We found that platelet CD62p expression by flow cytometry was elevated in 10\/15 (66.7%) <i>H. pylori<\/i>-infected patients, which is a statistically significant difference when compared with 3\/33 (9.1%) control ITP patients seronegative for <i>H. pylori <\/i>(p = 0.002). In addition, eradication therapy decreased CD62p expression (p = 0.04). However, reduction in platelet activation was not associated with an increase in platelet counts (mean 72.4 \u00d7 10<sup>9<\/sup>\/l before and 68.7 after therapy; p = 0.4). <i>Conclusion:<\/i> In our series, platelet activation was common in ITP patients with <i>H. pylori,<\/i> and eradication therapy decreased platelet activation but seldom increased platelet counts. Increased platelet CD62p expression is a putative link between chronic infections and atherosclerosis, but further study is needed to clarify the implications of our observation.<\/jats:p>","DOI":"10.1159\/000092343","type":"journal-article","created":{"date-parts":[[2006,6,28]],"date-time":"2006-06-28T10:30:06Z","timestamp":1151490606000},"page":"19-24","source":"Crossref","is-referenced-by-count":31,"title":["Platelet Activation in <i>Helicobacter pylori<\/i>-Associated Idiopathic Thrombocytopenic Purpura: Eradication Reduces Platelet Activation but Seldom Improves Platelet Counts"],"prefix":"10.1159","volume":"116","author":[{"given":"Eugene R.","family":"Ahn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maike P.","family":"Tiede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenche","family":"Jy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos J.","family":"Bidot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon S.","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2960004-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood.V97.3.812"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2002.03612.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02983780"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2003.04735.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2005.41641.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0609.2004.00220.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2001.03194.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2003-03-0900"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2002-11-3486"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.dld.2004.10.015"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI119650"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2803%2900397-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1083-4389.2004.00271.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2899%2970065-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-5378.2001.00028.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jvs.2003.09.042"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ehj.2003.08.021"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1067%2Fmcp.2003.13"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92343","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:03:12Z","timestamp":1745463792000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000092343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000092343","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}