{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:57:41Z","timestamp":1789387061106,"version":"build-2803163510"},"reference-count":7,"publisher":"S. Karger AG","issue":"4-5","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathophysiol Haemos Thromb"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>Pentapharm Ltd. has a long tradition of producing and proceeding snake venom components as APIs and tools in pharmaceutical and diagnostic applications, beginning with the snake venom-derived product Reptilase&lt;sup&gt;\u00ae&lt;\/sup&gt; about 60 years ago. In recent years diagnostic test kits in the field of haemostasis have been developed, like Pefakit&lt;sup&gt;\u00ae&lt;\/sup&gt; APC-R Factor V Leiden and Pefakit&lt;sup&gt;\u00ae&lt;\/sup&gt; PiCT&lt;sup&gt;\u00ae&lt;\/sup&gt;, which make use of one or more snake venom compounds as key reactants. The venom-derived compounds are responsible for many outstanding properties of these tests and account for their top ranking performance qualities confirmed in non-clinical and clinical studies. Both tests are on the market in Europe. Pefakit&lt;sup&gt;\u00ae&lt;\/sup&gt; APC-R Factor V Leiden is also marketed in the US since January 2005. Research on snake venom-derived compounds for diagnostic and pharmaceutical use is ongoing.<\/jats:p>","DOI":"10.1159\/000092430","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T13:49:21Z","timestamp":1148651361000},"page":"234-240","source":"Crossref","is-referenced-by-count":33,"title":["The Use of Snake Venom-Derived Compounds for New Functional Diagnostic Test Kits in the Field of Haemostasis"],"prefix":"10.1159","volume":"34","author":[{"given":"Reto","family":"Sch\u00f6ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0041-0101%2802%2900175-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.1971.tb03415.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000054187"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.119.1_suppl.64S"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1309%2FT8AV-VH7Q-WGL0-QTF5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.90.3.1004"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.toxicon.2005.02.019"}],"container-title":["Pathophysiology of Haemostasis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:03:42Z","timestamp":1745463822000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000092430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":7,"journal-issue":{"issue":"4-5","published-online":{"date-parts":[[2006,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000092430","archive":["Portico"],"relation":{},"ISSN":["1424-8832","1424-8840"],"issn-type":[{"value":"1424-8832","type":"print"},{"value":"1424-8840","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}