{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:58:57Z","timestamp":1761742737104,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; C-kit receptor expressing interstitial cells generate and coordinate the electrical signals that control peristalsis in the gut. However, the function of interstitial cells in the myometrium is not known. &lt;i&gt;Methods:&lt;\/i&gt; (1) Sections of rabbit myometrium were subjected to immunohistochemical staining for the c-kit receptor. (2) Spontaneously contracting myometrial strips from New Zealand White rabbits near term were mounted in an organ bath and attached to a tension-recording device. The effect of increased concentrations of the c-kit receptor antagonist imatinib mesylate on these contractions was observed. The main outcome measures were the change in frequency, amplitude and duration of contraction. &lt;i&gt;Results:&lt;\/i&gt; (1) Multipolar cells expressing c-kit were identified in the fibromuscular septum confirming the presence of interstitial cells in rabbit myometrium. (2) Imatinib decreased the amplitude of contractions by approximately 20% at 100 \u00b5&lt;i&gt;M&lt;\/i&gt;. No effect was seen at lower concentrations. No effect of imatinib on frequency or duration of contractions was observed at any of the concentrations studied. &lt;i&gt;Conclusions:&lt;\/i&gt; In isolated rabbit myometrium, acute inhibition of the c-kit receptor by imatinib mesylate affects only the amplitude of spontaneous contractions at concentrations, the equivalent of \u00d710\u2013100 the normal therapeutic concentration.<\/jats:p>","DOI":"10.1159\/000092530","type":"journal-article","created":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T14:24:28Z","timestamp":1144074268000},"page":"79-83","source":"Crossref","is-referenced-by-count":19,"title":["The Effect of Imatinib Mesylate on the Contractility of Isolated Rabbit Myometrial Strips"],"prefix":"10.1159","volume":"62","author":[{"given":"G.","family":"Hutchings","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Deprest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Nilius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Roskams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"De Ridder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F01.gco.0000169104.85128.0e"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00006254-200010000-00025"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2911476-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1071-5576%2800%2900041-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1113%2Fjphysiol.2003.043299"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1254%2Fjphs.CRJ04002X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000084021"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.autneu.2004.08.004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1582-4934.2005.tb00366.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1095%2Fbiolreprod.104.033506"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3468%2896%2990327-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.51.4.496"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2004-08-3097"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-7793.1997.241bc.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2899%2970560-3"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:04:24Z","timestamp":1745463864000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000092530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000092530","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[2006]]}}}