{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:00:39Z","timestamp":1789909239262,"version":"4.0.1"},"reference-count":18,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Background:<\/i> Recent studies have shown how the topical application of nerve growth factor (NGF) has led to the repair of neurotrophic corneal ulcers with recovery of corneal surface sensitivity. The biological effect of NGF, at a corneal level, is mediated by the presence of specific receptors localized on the surfaces of the corneal and conjunctival cells. <i>Objectives:<\/i> To evaluate the efficacy of NGF to promote corneal wound healing after cataract surgery. <i>Methods:<\/i> Thirty patients were divided into two groups (groups A and B) and underwent cataract surgery. After surgery patients in group A received 1 drop of NGF solution (10 \u00b5g of NGF dissolved in 50 \u00b5l of saline solution, 0.9% of sodium chloride) in the conjunctival fornix every 2 h (from 6 a.m. to 12 p.m.) for 2 weeks and then 4 times a day for another week. The patients in group B received 1 drop of hyaluronic acid 0.2% eye drops in the conjunctival fornix every 2 h for 2 weeks and then 4 times a day for another week. With optical coherence tomography (OCT) we evaluated the corneal thickness at the side of the surgical wound, the endothelial cell count and the incision line in the stroma 1, 7 and 21 days after surgery. <i>Results:<\/i> Before surgery in group A and in group B, the endothelial cell count was 2,607.4 \u00b1 261.0 versus 2,602.0 \u00b1 266.6 (p < 0.991), and the temporal cornea edge thickness was 639.2 \u00b1 24.7 versus 644.4 \u00b1 31.9 \u00b5m (p < 0.605), respectively. At 24 h after surgery, the results were: 2,523.2 \u00b1 280.5 versus 2,528.2 \u00b1 235.7 (p < 0.988) and 804.4 \u00b1 29.5 versus 802.6 \u00b1 35.0 \u00b5m (p < 0.953). After 7 days the cell count values were: 2,511.4 \u00b1 229.8 versus 2,490.0 \u00b1 230.4 (p < 0.361) and corneal thickness 713.6 \u00b1 16.5 versus 771.4 \u00b1 36.5 \u00b5m (p < 0.047). Finally, 21 days after surgery, the number of endothelial cells was 2,540.2 \u00b1 237.3 versus 2,503.4 \u00b1 224.5 (p < 0.382) and corneal thickness 645.2 \u00b1 22.6 versus 704.2 \u00b1 11.8 \u00b5m (p < 0.002). In the patients treated with NGF, on day 21, we found with OCT a complete wound healing, and the stromal incision was not visible. <i>Conclusions:<\/i> This clinical experience shows that the topical administration of NGF is effective in accelerating the healing of surgical corneal wounds.<\/jats:p>","DOI":"10.1159\/000092626","type":"journal-article","created":{"date-parts":[[2006,5,5]],"date-time":"2006-05-05T10:43:21Z","timestamp":1146825801000},"page":"177-181","source":"Crossref","is-referenced-by-count":35,"title":["The Use of Nerve Growth Factor in Surgical Wound Healing of the Cornea"],"prefix":"10.1159","volume":"38","author":[{"given":"M.","family":"Cellini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bendo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.O.","family":"Bravetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.C.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,8,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.3306916"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000052075"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0301-0082%2896%2900010-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2800%2900163-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199804233381702"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fjnr.490320402"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02532343"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.64.2.787"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2801%2901382-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2899%2900022-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F00003226-200107000-00008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-4547%2820000801%2961%3A3%3C263%3A%3AAID-JNR4%3E3.0.CO%3B2-M"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-4547%2820000801%2961%3A3%3C237%3A%3AAID-JNR1%3E3.0.CO%3B2-M"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2891%2990628-C"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ico.0000136666.63870.18"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.101130898"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1067%2Fmlc.2002.128347"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.04-1103"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:05:04Z","timestamp":1745463904000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000092626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000092626","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}