{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:08:54Z","timestamp":1745554134531,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; We investigated the effect of human growth hormone (GH) on newborn rat brain superoxide dismutase, glutathione and malondialdehyde (MDA) levels in hypoxic-ischemic (H-I) newborn rats. &lt;i&gt;Methods:&lt;\/i&gt; Fourty-eight 7 days old newborn rats were randomized to a healthy (n: 15), H-I (n: 18) and GH administered H-I (GH-H-I, n: 15) group. Permanent, left common carotid ligation was performed in the H-I groups. In the GH-H-I group, 50 mg\/kg human GH (Norditropin Simplex, Novo Nordisk A\/S) was administered subcutaneously just before carotid artery ligation. Two hours after ligation, rats were subjected to 2 h of hypoxemia and then were decapitated. Right and left cerebral hemispheres (CHs) and cerebellum-brain stem (C-BS) were separated. &lt;i&gt;Results:&lt;\/i&gt; Glutathione levels of each region were not statistically different from each other in and between the groups. Superoxide dismutase levels were higher in C-BSs compared to CHs (for each comparison p &lt; 0.01). CHs and C-BS MDA levels were similar in the control and H-I groups but MDA levels of both CHs of the GH-H-I group were significantly higher than the levels of the H-I group (p = 0.01; p = 0.024, respectively). Left CH MDA level of GH-H-I group was higher compared to left CH MDA of the control group (p = 0.045) while there was no difference between right CHs. In the GH-H-I group, left CH MDA level was higher than the C-BS (p = 0.03). MDA levels of the C-BSs did not differ between the groups (p &gt; 0.05). &lt;i&gt;Conclusion:&lt;\/i&gt; Although we have not evaluated the effect of GH histopathologically, increased lipid peroxidation especially in the H-I (left) hemisphere of the GH treated rats might suggest that GH treatment may be harmful in H-I encephalopathy.<\/jats:p>","DOI":"10.1159\/000092680","type":"journal-article","created":{"date-parts":[[2006,4,20]],"date-time":"2006-04-20T08:26:15Z","timestamp":1145521575000},"page":"168-173","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Human Growth Hormone on Superoxide Dismutase Activity, Glutathione and Malondialdehyde Levels of Hypoxic-Ischemic Newborn Rat Brain"],"prefix":"10.1159","volume":"90","author":[{"given":"Hacer","family":"Yap\u0131c\u0131o\u011flu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Satar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Necmiye","family":"Canacankatan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ercan","family":"Tutak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u015far","family":"Sertdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efsun","family":"Antmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nejat","family":"Narl\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0891-5849%2898%2900196-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-3806%2893%2990008-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199903000-00005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-4522%2801%2900109-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neulet.2003.09.070"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1385%2FENDO%3A11%3A1%3A41"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0891-5849%2800%2900186-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00004630-199811000-00015"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.2002.01493.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00315011"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2897%2900776-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0891-5849%2892%2990143-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.1984.tb09728.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199705000-00001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2897%2900907-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fmend-1-3-233"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.139.10.4364"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291521-4141%28199901%2929%3A01%3C334%3A%3AAID-IMMU334%3E3.0.CO%3B2-S"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177%2F0148607198022006368"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-328X%2899%2900051-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159%2F000126813"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2F0168-0102%2895%2900937-O"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2F0891-5849%2894%2990242-9"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2802%2900983-7"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:05:26Z","timestamp":1745463926000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000092680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2006,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000092680","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2006]]}}}