{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T16:02:33Z","timestamp":1779379353801,"version":"3.53.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Recent research has attempted combinations of instruments to improve screening accuracy for mild cognitive impairment (MCI) and early Alzheimer\u2019s disease (AD). We compared Mini-Mental State Examination (MMSE), Immediate and Delayed Recall (Logical Memory I and II; LM-I and LM-II, respectively), a single-item informant report of memory problem (IRMP), and a four-item Instrumental Activities of Daily Living (4IADL) scale, and combinations of these tests. &lt;i&gt;Method:&lt;\/i&gt; The tests were administered together with Clinical Dementia Rating (CDR) to subjects who were cognitively intact (CDR = 0, n = 88), and with diagnoses of MCI (CDR = 0.5, n = 37) and early AD (CDR = 1\u20132, n = 19). &lt;i&gt;Results:&lt;\/i&gt; Screening accuracy (receiver operating characteristic area under curve, AUC) for identifying MCI or MCI-AD was lowest for MMSE (AUC 67.6% for MCI or 77.9% for MCI-AD), and better for IRMP (79.5 or 83.2%), 4IADL (76.9 or 84.7%), LM-I (81.2 or 87.1%) and LM-II (86.1 or 90.8%). Combining IRMP, 4IADL and LM-II was most accurate (AUC 91.7% for MCI or 94.5% for MCI-AD); sensitivity: 86.5 or 89.3%; specificity: 86.4 or 88.6%. However, combining IRMP and 4IADL gave nearly as good accuracy (AUC 87.2 or 91.6%); sensitivity: 86.5 or 85.7%; specificity: 79.5 or 85.2%. &lt;i&gt;Conclusion:&lt;\/i&gt; A brief instrument combining an IRMP and 4IADL items is potentially useful in screening for MCI and early AD.<\/jats:p>","DOI":"10.1159\/000092808","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T13:49:21Z","timestamp":1148651361000},"page":"392-402","source":"Crossref","is-referenced-by-count":44,"title":["Brief Informant Screening Test for Mild Cognitive Impairment and Early Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"21","author":[{"given":"Minglei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze Pin","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ee Heok","family":"Kua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Meng","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,5,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2899%2906155-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.744"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2889%2990021-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00002093-199803000-00001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.1042"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.59.4.601"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fageing%2F26.5.393"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0895-4356%2892%2990135-A"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1017%2FS0033291700022418"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0404.107.s179.8.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.477"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-4356%2802%2900599-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fageing%2Fafg088"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-4356%2803%2900009-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.23.1.56"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0895-4356%2888%2990034-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291099-1166%28200003%2915%3A3%3C234%3A%3AAID-GPS99%3E3.0.CO%3B2-G"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F00002093-199700112-00005"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.56.3.303"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0447.1992.tb03225.x"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:07:05Z","timestamp":1745464025000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000092808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":21,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2006,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000092808","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}