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Several co-morbidities (i.e., necrotizing enterocolitis, intracranial hemorrhage, pulmonary edema\/hemorrhage, bronchopulmonary dysplasia, and retinopathy) are associated with the presence of a PDA, but whether or not a PDA is responsible for their development is still unclear. In this review, comparative physiology between the full term and preterm newborn and the barriers preventing the necessary cascade of events leading to permanent constriction of the PDA are reviewed.<\/jats:p>","DOI":"10.1159\/000092870","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T09:57:59Z","timestamp":1149069479000},"page":"330-335","source":"Crossref","is-referenced-by-count":204,"title":["Mechanisms Regulating the Ductus Arteriosus"],"prefix":"10.1159","volume":"89","author":[{"given":"Ronald I.","family":"Clyman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,6,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/en.135.2.798"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2882%2980247-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2805%2981553-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2809%2990044-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0008-6363%2896%2900171-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-198902000-00006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199909000-00010"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0090-6980%2878%2990028-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0090-6980%2878%2990051-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2880%2980205-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0090-6980%2881%2990095-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0959-437X(95)80025-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.73.2.177"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-7793.2001.0253b.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2902452-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.12.7946"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.01.005"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2881%2980557-4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.02.016"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000241135"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.108.3.741"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2F5538"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038%2F36342"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.031573498"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.176"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1126\/science.3037703"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2896%2980123-5"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200106283442602"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2887%2980126-9"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2894%2970210-1"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198906083202302"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2880%2980336-2"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2883%2980022-5"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/966"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1159%2F000241348"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5476.119"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.07.018"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/92870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:07:32Z","timestamp":1745449652000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000092870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000092870","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}