{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:34:02Z","timestamp":1760297642418,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Objectives:<\/i> We assessed the safety and efficacy of docetaxel, a microtubule inhibitor, in patients with advanced hepatocellular carcinoma (HCC). <i>Methods:<\/i> HCC patients that were not suitable for local therapy, but who possessed measurable disease, good performance status and adequate organ function were eligible. Docetaxel was administered every 3 weeks at a dose of 100 mg\/m<sup>2<\/sup> (or 75 mg\/m<sup>2<\/sup> if transaminase levels were between 1.5 and 3.5 times the upper normal limit). Efficacy was assessed radiologically every three cycles of chemotherapy. <i>Results:<\/i> Fifteen patients were enrolled: 11 males and 4 females; their median age was 64 years (range, 42\u201372 years). Nine patients had underlying cirrhosis. Four patients had been surgically treated before relapse (liver resection in 3 cases and transplantation in 1), 3 had been treated with arterial chemoembolization and 1 with arterial chemotherapy (doxorubicin). A total of 57 cycles of docetaxel were delivered (median 3, range 1\u20136). Significant toxicity was observed: mostly grade 3\u20134 neutropenia and fatigue (6 and 4 patients, respectively). Treatment had to be stopped because of toxicity in 6 patients, all having underlying cirrhosis. An important partial response was obtained in 1 patient, a result that enabled liver transplantation; this patient is still alive after 34 months. Five patients had transient stable disease. <i>Conclusion:<\/i> When used in this schedule, docetaxel does not appear to be safe and effective enough in patients with advanced HCC and cirrhosis.<\/jats:p>","DOI":"10.1159\/000093007","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T13:49:21Z","timestamp":1148651361000},"page":"154-158","source":"Crossref","is-referenced-by-count":25,"title":["Phase II Trial of Docetaxel Therapy in Patients with Advanced Hepatocellular Carcinoma"],"prefix":"10.1159","volume":"70","author":[{"given":"Mohamed","family":"Hebbar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Cattan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina","family":"Oprea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Mathurin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Triboulet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Paris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois-Ren\u00e9","family":"Pruvot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,5,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1089-3261%2805%2970155-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejca.2004.02.027"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.1998.00286.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1008383707159"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2820000901%2989%3A5%3C983%3A%3AAID-CNCR7%3E3.0.CO%3B2-G"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.10751"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhep.2004.07.015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F92.3.205"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28197510%2936%3A4%3C1250%3A%3AAID-CNCR2820360410%3E3.0.CO%3B2-X"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00535-005-1566-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2820010101%2991%3A1%3C101%3A%3AAID-CNCR13%3E3.0.CO%3B2-K"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1005851804533"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000058526"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000012162"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.20841"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.11869"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1746.2004.03737.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2820000101%2988%3A1%3C180%3A%3AAID-CNCR25%3E3.0.CO%3B2-Q"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-8049%2897%2900340-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2165%2F00003088-199936020-00002"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%28197705%2939%3A5%3C1923%3A%3AAID-CNCR2820390502%3E3.0.CO%3B2-2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097%2F00130404-200403000-00005"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:08:33Z","timestamp":1745464113000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000093007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000093007","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"type":"print","value":"0030-2414"},{"type":"electronic","value":"1423-0232"}],"subject":[],"published":{"date-parts":[[2006]]}}}