{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:51:48Z","timestamp":1761540708366,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathophysiol Haemos Thromb"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>A 17-year-old girl presented with &lt;i&gt;Neisseria meningitidis&lt;\/i&gt; sepsis, with evidence of disseminated intravascular coagulation. Substitution therapy with both antithrombin and protein C concentrates was initiated, leading to clinical and biological improvement. Sequential dosages were performed for biological markers including thrombin-activatable fibrinolysis inhibitor (TAFI). Substitution therapy with both antithrombin and protein C concentrates led to a clinical and biological improvement. Biological markers showed a decrease in thrombin generation and in plasminogen activator inhibitor 1 (PAI-1) and a return of TAFI to a normal value. Discontinuation of substitutive treatment was marked by a clinical relapse at 24 h, with thrombin generation and increase in PAI-1, while TAFI remained unchanged. This report shows the evolution of hemostasis markers during septic shock and provides new data concerning the effects of a substitutive therapy.<\/jats:p>","DOI":"10.1159\/000093109","type":"journal-article","created":{"date-parts":[[2006,6,14]],"date-time":"2006-06-14T14:16:44Z","timestamp":1150294604000},"page":"284-287","source":"Crossref","is-referenced-by-count":3,"title":["Evolution of Thrombin Formation and Fibrinolysis Markers, Including Thrombin-Activatable Fibrinolysis Inhibitor, during Severe Meningococcemia"],"prefix":"10.1159","volume":"34","author":[{"given":"Marc","family":"Fouassier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Thiolli\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Fr\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Marqu\u00e8s-Verdier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Souweine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200103083441001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F01.CCM.0000072121.61120.D8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00134-003-1784-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1086%2F319995"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200108093450603"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199908193410807"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.124.3_suppl.33S"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2141.2000.01890.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0049-3848%2801%2900331-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1538-7836.2004.00557.x"}],"container-title":["Pathophysiology of Haemostasis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:09:51Z","timestamp":1745464191000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000093109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2006,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000093109","archive":["Portico"],"relation":{},"ISSN":["1424-8832","1424-8840"],"issn-type":[{"type":"print","value":"1424-8832"},{"type":"electronic","value":"1424-8840"}],"subject":[],"published":{"date-parts":[[2005]]}}}