{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:08:13Z","timestamp":1761988093701,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Many neonatal diseases have been associated with oxidative stress and altered nitric oxide status. &lt;i&gt;Objective:&lt;\/i&gt; To determine the effects of clinical interventions on the levels of urinary peroxides, a marker of oxidative stress, and urinary nitrate\/nitrites, indices of nitric oxide production and metabolism, in the first 72 h of life in premature infants. &lt;i&gt;Methods:&lt;\/i&gt; A single, spot urine sample was collected from 82 premature and 20 healthy term infants within the first 72 h of life. The peroxide levels were quantified using a fluorometric method, and nitrate\/nitrite levels were quantified by chemiluminescence. &lt;i&gt;Results:&lt;\/i&gt; Premature infants had a median peroxide level of 10.0 \u00b5mol\/mmol creatinine (Cr) (interquartile range 4.8\u201320.0 \u00b5mol\/mmol Cr). These values were significantly higher than term infants (median 5.0 \u00b5mol\/mmol Cr, interquartile range 2.7\u201310.0 \u00b5mol\/mmol Cr). Urinary nitrate\/nitrite levels were not significantly different between preterm (220.5 \u00b5mol\/mmol Cr, interquartile range 161\u2013287 \u00b5mol\/mmol Cr) and healthy term infants (244 \u00b5mol\/mmol Cr, interquartile range 194\u2013316 \u00b5mol\/mmol Cr). For urinary peroxides, infants on TPN had significantly higher urinary peroxide levels than infants who were not on TPN at the time of urine collection (p = 0.006). Administration of indomethacin was associated with lower levels of urinary nitrate\/nitrites (p = 0.0003). Both effects remained significant after controlling for gestational age, degree of respiratory distress and day of urine collection. &lt;i&gt;Conclusion:&lt;\/i&gt; Monitoring the level of both peroxides and nitrate\/nitrite may offer added information about the degree of oxidative stress experienced by a newborn but needs to account for clinical and therapeutic interventions.<\/jats:p>","DOI":"10.1159\/000093633","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T13:57:59Z","timestamp":1149083879000},"page":"233-242","source":"Crossref","is-referenced-by-count":16,"title":["Urinary Metabolites of Oxidative Stress and Nitric Oxide in Preterm and Term Infants"],"prefix":"10.1159","volume":"90","author":[{"given":"Christiana R.","family":"Farkouh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Merrill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip L.","family":"Ballard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta A.","family":"Ballard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Ischiropoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Lorch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,11,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.105.1.232"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199101000-00008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199601000-00017"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-197602000-00010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-198910000-00016"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.112.2.296"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000080950"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clp.2004.04.021"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199407001-00009"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053%2Fsper.2001.23188"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000244437"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1442-200X.2002.01584.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000244499"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00204-005-0658-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000164572.92049.29"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.freeradbiomed.2004.10.024"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bcp.2003.09.023"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-8703%2896%2990271-9"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0899-9007%2802%2900742-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1006%2Fabio.1997.2391"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000134256.30519.9B"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M210806200"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1080%2F1071576021000033112"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1993.tb12662.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2000.105131"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000016664.46604.01"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159%2F000063609"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.1999.1263"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:14:05Z","timestamp":1745464445000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000093633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000093633","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2006]]}}}