{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:17:56Z","timestamp":1791263876231,"version":"4.1.0"},"reference-count":7,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; Creutzfeldt-Jakob disease (CJD) is not only a disorder of the central nervous system but also affects the skeletal muscle. Subclinical skeletal muscle involvement, manifesting as hyper-creatine-kinase (CK)-emia, is rare. &lt;i&gt;Case Report:&lt;\/i&gt; The patient, a 60-year-old male, developed progressive dementia, accompanied by dysphagia and bursts of aggression, disorientation and optic hallucinations. Five months after onset of the cognitive decline, hyper-CK-emia of 117 U\/l (normal: &lt;81 U\/l) was noted for the first time. During 12 months until decease, hyper-CK-emia was permanently present and reached a maximum of 354 U\/l. Hyper-CK-emia was attributed to subclinical involvement of the skeletal muscle in CJD. Hyper-CK-emia due to progressive brain damage, double trouble of an additional primary myopathy or due to excessive myoclonic jerking was excluded. &lt;i&gt;Conclusions:&lt;\/i&gt; This case shows that CJD may be present with mild hyper-CK-emia in individual patients, most likely due to concomitant undiagnosed involvement of the skeletal muscle in the primary disease.<\/jats:p>","DOI":"10.1159\/000093659","type":"journal-article","created":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T12:16:55Z","timestamp":1153138615000},"page":"264-266","source":"Crossref","is-referenced-by-count":1,"title":["Creatine Kinase Elevation in Creutzfeldt-Jakob Disease"],"prefix":"10.1159","volume":"52","author":[{"given":"Josef","family":"Finsterer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Gelpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.59.9.1430"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa030351"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177%2F153331750301800309"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.10813"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fmus.880151103"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS1388-2457%2800%2900364-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00127893-200006060-00001"}],"container-title":["Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:14:22Z","timestamp":1745464462000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000093659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000093659","archive":["Portico"],"relation":{},"ISSN":["0304-324X","1423-0003"],"issn-type":[{"value":"0304-324X","type":"print"},{"value":"1423-0003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}