{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T10:30:10Z","timestamp":1749119410606,"version":"3.40.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Backgrounds\/Aims:<\/i> Turner syndrome is not usually associated with thrombotic events. The aim of this study is to report 3 Turner syndrome patients with portal vein thrombosis and, in 2 of them, high factor VIII. These findings are compared to values in Turner syndrome patients without thrombosis and controls. <i>Methods:<\/i> In different years, 3 patients with Turner syndrome were initially seen at the Gastroenterology Clinic of Hospital de Cl\u00ednicas de Porto Alegre, Brazil, for portal vein thrombosis. After the most common causes of portal vein thrombosis and thrombophilias had been excluded, the 2 surviving patients were studied for clotting factors VIII, IX and von Willebrand factor. The same factors were also assessed in 25 Turner syndrome patients without thrombosis and 25 normal girls. <i>Results:<\/i> One of the patients with portal vein thrombosis died before the study. In the 2 surviving patients, factors VIII and von Willebrand levels were >150 IU\/dl, which is considered to be high. In Turner syndrome patients without thrombosis, the mean factor VIII level was 127.2 \u00b1 41.1 IU\/dl and for von Willebrand factor 101.2 \u00b1 26.9 IU\/dl, while in control girls these were 116.0 \u00b1 27.6 and 94.28 \u00b1 27.5 IU\/dl, respectively. Factor VIII and von Willebrand factor were not different between these 2 groups. When non-O blood group Turner syndrome patients and normal girls were compared, the former had significantly higher levels of factor VIII. <i>Conclusions:<\/i> This is the first report on the unusual finding of portal thrombosis in patients with Turner syndrome in whom high levels of factor VIII and von Willebrand factor were found. Factor VIII is higher in the non-O blood group Turner syndrome patients without thrombosis when compared to normal girls.<\/jats:p>","DOI":"10.1159\/000093693","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T13:57:59Z","timestamp":1149083879000},"page":"89-93","source":"Crossref","is-referenced-by-count":14,"title":["Portal Vein Thrombosis and High Factor VIII in Turner Syndrome"],"prefix":"10.1159","volume":"66","author":[{"given":"Cristiane","family":"Kopacek Zilz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Keller Brenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina Helena","family":"Elnecave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra030360"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2801%2905487-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.7.3061"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.111.3.692"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-4356%2897%2900237-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpedsurg.2004.05.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2895%2990166-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200003093421004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200008173430702"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa032959"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1442-200X.2003.01683.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa040161"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2001.24506"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2002-32122"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1023%2FB%3ADDAS.0000007877.17861.0a"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1538-7836.2004.00851.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.seminhematol.2004.09.009"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2004.01117.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1538-7836.2003.00080.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2907779-6"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000142290.35842.B0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.20026"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.2002.01523.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2802%2907779-6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.293.19.2352"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mehy.2005.02.030"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:14:44Z","timestamp":1745464484000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000093693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000093693","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2006]]}}}