{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:36:09Z","timestamp":1760204169381,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background and Objectives:&lt;\/i&gt; Different types of surfactant preparations were shown not to exert uniform response in preterm infants suffering from respiratory distress syndrome (RDS). Therefore, the effects of a recombinant surfactant protein C (rSP-C) based preparation and a natural surfactant were compared applying different levels of positive end-expiratory pressure (PEEP) in experimental RDS. &lt;i&gt;Methods:&lt;\/i&gt; Preterm rabbits (n = 7\u201314 per group; 27 days gestation; term 30 days) were randomized for receiving either 100 mg\/kg rSP-C or natural bovine surfactant and were compared with saline treated controls. Animals were ventilated for 30 min with either 0.3 or 0 kPa PEEP at standardized tidal volumes and lung mechanics were measured as well as lung histology and mRNA expression of surfactant associated proteins B and C by real-time PCR. &lt;i&gt;Results:&lt;\/i&gt; The PEEP level applied (0.3 vs. 0 kPa) largely influenced dynamic compliance after administration of rSP-C surfactant (4.45 vs. 2.58 ml\/kg), whereas natural surfactant improved compliance regardless of the PEEP applied (4.86 vs. 4.24 ml\/kg) compared to controls (2.41 vs. 1.55 ml\/kg). Accordingly, administration of PEEP significantly increased alveolar count in all groups as well as SP-C mRNA expression, whereas SP-B expression and protein content both remained unchanged. &lt;i&gt;Conclusion:&lt;\/i&gt; Response to rSP-C surfactant depends on the PEEP level applied in our model of neonatal RDS. These findings should be considered for the conception of clinical trials regarding treatment strategies in neonatal RDS.<\/jats:p>","DOI":"10.1159\/000093820","type":"journal-article","created":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T12:19:19Z","timestamp":1149855559000},"page":"210-216","source":"Crossref","is-referenced-by-count":7,"title":["Positive End-Expiratory Pressure Modifies Response to Recombinant and Natural Exogenous Surfactant in Ventilated Immature Newborn Rabbits"],"prefix":"10.1159","volume":"90","author":[{"given":"Anne","family":"Hilgendorff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin","family":"Reiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Ruppert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thilo","family":"Hanfstingl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann Sophie","family":"Seliger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"G\u00fcnther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Ebsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludwig","family":"Gortner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI117173"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199109000-00007"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra022387"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2004-819002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-2231"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-2183"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00134-003-1984-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199508000-00013"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-6576.1999.431005.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2887%2980354-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1986.tb10155.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199604000-00025"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000054655.95452.06"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200304-544OC"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000056766"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:15:54Z","timestamp":1745464554000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000093820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2006,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000093820","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2006]]}}}