{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:57:37Z","timestamp":1761512257217,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Background:<\/i> Treatment of short children born small for gestational age (SGA) with recombinant human growth hormone (r-hGH) increases growth velocity during childhood. As in other indications, the growth velocity in these patients is more marked during the first year of treatment and then decreases. This study was undertaken to evaluate the efficacy of different r-hGH treatment schedules (67 \u00b5g\/kg\/day in a discontinuous or continuous regimen) during the second year of r-hGH treatment by comparing height velocity changes and total gain of height over a 4-year period. <i>Methods:<\/i> 58 growth-retarded SGA children aged 2\u20135 years were randomized to a TOTO regimen [4 years alternating treatment (T) and observation (O), n = 30] or a TTOO regimen (2 years\u2019 treatment, followed by 2 years\u2019 observation, n = 28). Height velocity (HV) and total height gain were assessed during the 4-year study. <i>Results:<\/i> In both groups, HV and HV standard deviation score (HV-SDS<sub>CA<\/sub>) increased during treatment and decreased during observation periods. Interruption of treatment in the TOTO group did not result in a better gain in height standard deviation score (H-SDS<sub>CA<\/sub>) when compared with the TTOO group. After 4 years of study, the gain in H-SDS<sub>CA<\/sub> was 1.4 \u00b1 01 in the TOTO group and 1.6 \u00b1 0.2 in the TTOO group leading to a mean height of \u20132.0 \u00b1 1.0 SDS and \u20132.0 \u00b1 0.8 SDS, respectively. The rate of bone maturation was similar in the two groups. <i>Conclusions:<\/i> In short SGA children, TOTO and TTOO regimens produced significant improvements in growth during r-hGH treatment. However, treatment interruption after 1 year did not influence the overall gain in height SDS when compared with 2 years\u2019 continuous treatment.<\/jats:p>","DOI":"10.1159\/000093832","type":"journal-article","created":{"date-parts":[[2006,6,14]],"date-time":"2006-06-14T14:16:44Z","timestamp":1150294604000},"page":"118-123","source":"Crossref","is-referenced-by-count":1,"title":["Intermittent Recombinant Growth Hormone Treatment in Short Children Born Small for Gestational Age: Four-Year Results of a Randomized Trial of Two Different Treatment Regimens"],"prefix":"10.1159","volume":"66","author":[{"given":"D.","family":"Simon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Leger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fjellestad-Paulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Crabb\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Czernichow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199511000-00017"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199508000-00022"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1994.tb13292.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.102.6.e72"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080%2F08035259850158209"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.9.3064"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.8.2816"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-021172"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000148716.71231.81"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-020867"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-73-6-1269"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210%2Fendo-102-2-386"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1999.tb14357.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1510567"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.5.1462"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.81.11.4013"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-030962"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93832","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:16:05Z","timestamp":1745464565000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000093832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000093832","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2006]]}}}