{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:48:41Z","timestamp":1788306521669,"version":"build-2803163510"},"reference-count":7,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background and Purpose:&lt;\/i&gt; Congenital vertebral artery (VA) hypoplasia is an uncommon embryonic variation of posterior circulation. The frequency of this congenital variation was reported to be 2\u20136% from autopsy and angiograms. The aim of our study was to elucidate the role of VA hypoplasia in acute ischemic stroke. &lt;i&gt;Method:&lt;\/i&gt; We examined 191 acute ischemic stroke patients (age 55.8 \u00b1 14.0 years). TOAST subtypes were determined. A cervical magnetic resonance angiogram was performed in every patient. A duplex study of bilateral VA with flow velocities and vessel diameter recording in the intertransverse (V2) segment was performed within 72 h after onset of ischemic stroke. The net VA flow volume was measured in each subject. &lt;i&gt;Result:&lt;\/i&gt; The overall incidence of a unilateral congenital hypoplastic VA was 11.51%, which was statistically higher especially in cases of brainstem\/cerebellar infarction. Of these, subjects with VA hypoplasia had an etiological preponderance of the \u2018large-artery atherosclerosis\u2019 subtype and a topographic preponderance of ipsilateral posterior circulation infarction. &lt;i&gt;Conclusions:&lt;\/i&gt; Based on our results, VA hypoplasia seemed a contributing factor of acute ischemic stroke, especially in posterior circulation territories.<\/jats:p>","DOI":"10.1159\/000093868","type":"journal-article","created":{"date-parts":[[2006,6,14]],"date-time":"2006-06-14T14:16:44Z","timestamp":1150294604000},"page":"193-197","source":"Crossref","is-referenced-by-count":58,"title":["Toward a Further Elucidation: Role of Vertebral Artery Hypoplasia in Acute Ischemic Stroke"],"prefix":"10.1159","volume":"55","author":[{"given":"Yu-Ming","family":"Chuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuarn-Chung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Haw","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yih","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,8,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000125857.63427.59"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.1998.tb05973.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02189960"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067%2Fmva.1987.avs0050594"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00005072-196507000-00007"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejrad.2004.05.010"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F90.4.747"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/93868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:16:28Z","timestamp":1745464588000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000093868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000093868","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}