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Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Helicobacter pylori&lt;\/i&gt; is a Gram-negative, spiral bacterium that colonizes the gastric mucosa of at least 50% of the world\u2019s population and plays a causative role in the development of chronic gastritis as well as in gastric and duodenal ulcers. &lt;i&gt;H. pylori&lt;\/i&gt; triggers vigorous humoral and cellular immune responses in both systemic and mucosal compartments. In spite of this response, the vast majority of infected hosts are unable to clear the infection, and it persists for decades. Although &lt;i&gt;Helicobacter&lt;\/i&gt; is tolerated by a na\u00efve host organism, preclinical studies have demonstrated that prophylactic or therapeutic vaccinations efficiently clear &lt;i&gt;Helicobacter&lt;\/i&gt; from the stomach. The understanding of the mechanisms leading to the &lt;i&gt;Helicobacter&lt;\/i&gt; persistence or the vaccine-induced eradication of &lt;i&gt;Helicobacter &lt;\/i&gt;in animal models will help to define optimal immunization strategies for future anti-&lt;i&gt;Helicobacter &lt;\/i&gt;vaccination clinical trials.<\/jats:p>","DOI":"10.1159\/000094043","type":"journal-article","created":{"date-parts":[[2006,6,21]],"date-time":"2006-06-21T02:15:18Z","timestamp":1150856118000},"page":"116-123","source":"Crossref","is-referenced-by-count":27,"title":["Immunology of &lt;i&gt;Helicobacter pylori&lt;\/i&gt; 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