{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:01:55Z","timestamp":1788850915757,"version":"build-2803163510"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Upregulation of the platelet-derived growth factor receptor-\u03b1 (PDGFR\u03b1) in airway myofibroblast cells is one of the mechanisms of airway remodeling. The genetic association between PDGFR\u03b1 promoter polymorphism and severity of childhood asthma was examined. &lt;i&gt;Methods:&lt;\/i&gt; Five single nucleotide polymorphisms (SNPs) at the promoter regions of the PDGFR\u03b1 gene were genotyped in 277 unrelated allergic and nonallergic asthmatic children and 93 age-matched controls. Promoter haplotypes were constructed using SNP genotyping data. The serum level of PDGF-AA, the ligand for PDGFR\u03b1, was assayed by ELISA kits. &lt;i&gt;Results:&lt;\/i&gt; The genotype distribution of SNP rs1800810 (\u20131171G\/C) in nonallergic asthma was significantly different from controls (p = 0.038), as well as its allele distribution (p = 0.028). Using haplotype analysis, the combination frequency of the low expression of H1 homozygous and heterozygous genotype (H1\/H1 + H1\/H2) was significantly higher in nonallergic asthma as compared to controls (OR = 1.94, CI = 1.11\u20133.39, p &lt; 0.02). The frequency of H2\/H2 homozygous was higher in persistent asthma than in intermittent asthma (p = 0.008, OR = 2.625). In addition, the PDGF-AA serum level in H2\/H2 homozygous haplotype was significantly lower as compared to non-H2\/H2 homozygous haplotype both in asthmatic (138.1 \u00b1 62.9 vs. 249.7 \u00b1 97.1 ng\/ml, p &lt; 0.05) and nonallergic asthmatic children (113.8 \u00b1 38.0 vs. 256.6 \u00b1 58.3 ng\/ml, p &lt; 0.05). &lt;i&gt;Conclusions:&lt;\/i&gt; The developmental deficiency due to the low expression of PDGFR\u03b1 may be one of the susceptible factors for nonallergic asthmatic children. There was also an autocrine effect of lower PDGF-AA and higher PDGFR\u03b1 expression that might lead to airway remodeling causing the severity of asthma.<\/jats:p>","DOI":"10.1159\/000094180","type":"journal-article","created":{"date-parts":[[2006,6,28]],"date-time":"2006-06-28T10:30:06Z","timestamp":1151490606000},"page":"37-46","source":"Crossref","is-referenced-by-count":13,"title":["Variant in Promoter Region of Platelet-Derived Growth Factor Receptor-\u03b1 (PDGFR\u03b1) Gene Is Associated with the Severity and Allergic Status of Childhood Asthma"],"prefix":"10.1159","volume":"141","author":[{"given":"Lawrence Shih-Hsin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon-Yee","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Mei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherry Guan-Ju","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu-Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,8,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200102013440507"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.immunol.22.012703.104716"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.123.3_suppl.417S-a"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.86.13.4917"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2F84867"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10038-005-0248-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1006%2Fgeno.1994.1405"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2005.02278.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001090000111"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.2001.01197.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199810223391703"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200205-414OC"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.71.4.1207"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2003.162"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200308-1174OC"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1995.tb02493.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2001.111433"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Felps.200390024"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cytogfr.2004.03.006"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.123.3_suppl.422S"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:29:16Z","timestamp":1745461756000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000094180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000094180","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}