{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:57:20Z","timestamp":1784674640995,"version":"3.55.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"published-print":{"date-parts":[[2006]]},"abstract":"Adhesion of bacteria to pellicle-coated tooth surfaces is the first step in biofilm formation on teeth. The aim of this study was to explore whether human milk prevents or promotes adhesion of cariogenic <i>Streptococcus mutans <\/i>to saliva-coated hydroxyapatite (HA) using an in vitromodel system. <i>S. mutans<\/i> binding to HA coated with human parotid saliva (s-HA) or human milk was studied, in addition to binding inhibition to s-HA by human milk. <i>S. mutans <\/i>did not bind to HA coated with milk. <i>S. mutans <\/i>binding to s-HA was inhibited by milk from 15 (71 %) of 21 women, whereas milk from the remaining 6 mothers enhanced binding of <i>S. mutans<\/i> to s-HA. Inhibition of <i>S. mutans<\/i> binding correlated with bacterial binding to s-HA (r = 0.76). Human milk does not mediate adhesion of <i>S. mutans<\/i> to HA in vitro<i>,<\/i> but affects adhesion in an individually varying fashion. Phenotypic variations in milk and saliva glycosylation may explain the inhibitory capacity and possibly affect susceptibility to colonization by <i>S. mutans<\/i> in childhood.<\/jats:p>","DOI":"10.1159\/000094287","type":"journal-article","created":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T11:41:59Z","timestamp":1157110919000},"page":"412-417","source":"Crossref","is-referenced-by-count":28,"title":["Effects of Human Milk on Adhesion of <i>Streptococcus mutans <\/i>to Saliva-Coated Hydroxyapatite in vitro"],"prefix":"10.1159","volume":"40","author":[{"given":"J.","family":"Wernersson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Danielsson Niemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Einarson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Hernell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,8,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0882-4010%2890%2990090-D"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1098801"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.40.3.1001-1009.2002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-5793%2887%2981237-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-9969%2887%2990149-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177%2F00220345950740040301"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-302X.1998.tb00731.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.1983.tb26855.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.nutr.20.1.699"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177%2F00220345950740020901"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000016579"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1002054810170"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1128%2FIAI.73.4.2245-2252.2005"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1128%2FIAI.72.10.6181-6184.2004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177%2F00220345960750101101"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1177%2F00220345980770101301"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00005176-199510000-00006"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-9969%2894%2990059-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2F0-306-46830-1_7"}],"container-title":["Caries Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:30:17Z","timestamp":1745461817000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000094287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":19,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000094287","archive":["Portico"],"relation":{},"ISSN":["0008-6568","1421-976X"],"issn-type":[{"value":"0008-6568","type":"print"},{"value":"1421-976X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}