{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:21:39Z","timestamp":1778217699774,"version":"3.51.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Diacylglycerol (DAG) suppresses the postprandial increase in serum triglycerides, and has antiobesity effects. On the other hand, plant sterol esters (PSE) lower serum cholesterol levels in hypercholesterolemia. Thus, DAG-containing PSE (PSE\/DAG) would be expected to maintain an appropriate serum cholesterol level and decrease the risk of arteriosclerotic disorders. Several recent studies, however, report negative effects of PSE on serum fat-soluble (pro)vitamin levels. The objective of this study was to investigate the effect of PSE\/DAG on serum retinol, \u03b2-carotene, and \u03b1-tocopherol levels using a threefold excess of the effective dose obtained in our previous study. &lt;i&gt;Methods:&lt;\/i&gt; A randomized placebo-controlled double-blind parallel study was performed in healthy and mildly hypercholesterolemic subjects, in which the subjects ingested 1.2 g PSE\/30 g DAG for 2 weeks in the form of mayonnaise-type products. Triacylglycerol (TAG) mayonnaise was used as a control. &lt;i&gt;Result:&lt;\/i&gt; There were no subjective adverse effects or changes in serum retinol, \u03b1-tocopherol, and \u03b2-carotene levels, abdominal symptoms, hematologic values, or blood biochemical values. &lt;i&gt;Conclusion:&lt;\/i&gt; Ingestion of a threefold excess of PSE\/DAG for 2 weeks had no adverse effects compared to ingestion of conventional TAG mayonnaise.<\/jats:p>","DOI":"10.1159\/000094302","type":"journal-article","created":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T10:58:29Z","timestamp":1151751509000},"page":"372-379","source":"Crossref","is-referenced-by-count":5,"title":["Serum Retinol, \u03b1-Tocopherol, and \u03b2-Carotene Levels Are Not Altered by Excess Ingestion of Diacylglycerol-Containing Plant Sterol Esters"],"prefix":"10.1159","volume":"50","author":[{"given":"Shinichiro","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuichi","family":"Tomonobu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Shiiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Hase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Tokimitsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,8,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1271%2Fbbb.58.1416"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.nut.2005.05.013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00041433-200012000-00002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ejcn.1600728"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000046736"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11746-003-0843-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-2697%2885%2990321-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2005.03.015"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053%2Fmeta.2002.32021"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053%2Fmeta.2002.29988"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:30:31Z","timestamp":1745461831000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000094302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000094302","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}