{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:50:15Z","timestamp":1762113015679,"version":"3.40.4"},"reference-count":44,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Thalidomide inhibited tumor necrosis factor-\u03b1 (TNF-\u03b1) effectively in many trials. The aim of this study was to investigate the effect of thalidomide on the expression of nuclear factor-\u0138B (NF-\u0138B), inhibitor of NF-\u0138B (I\u0138B) and TNF-\u03b1 in a rat model of liver cirrhosis. &lt;i&gt;Methods:&lt;\/i&gt; Liver cirrhosis was achieved by intraperitoneal injection of carbon tetrachloride thrice weekly, and thalidomide (10 or 100 mg\/kg\/day) was given daily by intragastric route for 8 weeks. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), prealbumin (PA), hyaluronic acid (HA) and laminin (LN), and hydroxyproline (HYP), NF-\u0138Bp65, \u03b1-smooth muscle actin (\u03b1-SMA) protein and TNF-\u03b1 mRNA were studied in the liver, I\u0138B\u03b1 and TNF-\u03b1 protein in the cytoplasm and NF-\u0138Bp65 protein in the nucleus. &lt;i&gt;Results:&lt;\/i&gt; Compared with nontreated cirrhotic rats, the histopathology of rats given thalidomide (100 mg\/kg) was significantly better. Serum ALT, AST, HA and LN and HYP content in the liver were significantly decreased and PA was elevated (p &lt; 0.01) in this group; the expression of TNF-\u03b1 mRNA and protein, NF-\u0138Bp65 and \u03b1-SMA were significantly decreased and I\u0138B\u03b1 protein was also elevated (p &lt; 0.01). &lt;i&gt;Conclusion:&lt;\/i&gt; Thalidomide downregulates NF-\u0138B-induced TNF-\u03b1 and activates hepatic stellate cells (HSC) via inhibition of I\u0138B degradation to prevent liver cirrhosis.<\/jats:p>","DOI":"10.1159\/000094492","type":"journal-article","created":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T11:41:59Z","timestamp":1157110919000},"page":"82-92","source":"Crossref","is-referenced-by-count":14,"title":["Thalidomide in Rat Liver Cirrhosis: Blockade of Tumor Necrosis Factor-\u03b1 via Inhibition of Degradation of an Inhibitor of Nuclear Factor-\u03baB"],"prefix":"10.1159","volume":"73","author":[{"given":"Shelley 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