{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:46:18Z","timestamp":1789620378653,"version":"build-2803163510"},"reference-count":6,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>A 24-year-old female patient presented to her community hospital with mild elevations of serum transaminase and bilirubin levels. Because of multiple sclerosis, she was treated with interferon beta-1a for 6 weeks. After exclusion of viral hepatitis due to hepatitis A\u2013E, interferon beta-1a was withdrawn under the suspicion of drug-induced hepatitis. One week later, she was admitted again to her community hospital with severe icterus. The transaminase and bilirubin levels were highly elevated, and a beginning impairment of the liver synthesis was expressed by a reduced prothrombin time. The confinement to our department occurred with a fulminant hepatitis and the suspicion of beginning acute liver failure. There was no evidence for hepatitis due to potentially hepatotoxic viruses, alcoholic hepatitis, Budd-Chiari syndrome, hemochromatosis, and Wilson\u2019s disease. In her serum there were high titers of liver-kidney microsomal type 1 autoantibody; the serum gamma globulin levels were in the normal range. Fine-needle aspiration biopsy of the liver ruled out an autoimmune hepatitis but showed signs of drug-induced toxicity. During the interview, she admitted that for \u2018general immune system stimulation\u2019 she had been drinking Noni juice, a Polynesian herbal remedy made from a tropical fruit &lt;i&gt;(Morinda citrifolia)&lt;\/i&gt;, during the past 4 weeks. After cessation of the Noni juice ingestion, her transaminase levels normalized quickly and were in the normal range within 1 month.<\/jats:p>","DOI":"10.1159\/000094524","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T12:33:37Z","timestamp":1152707617000},"page":"167-170","source":"Crossref","is-referenced-by-count":45,"title":["Hepatitis Induced by Noni Juice from &lt;i&gt;Morinda citrifolia&lt;\/i&gt;: A Rare Cause of Hepatotoxicity or the Tip of the Iceberg?"],"prefix":"10.1159","volume":"73","author":[{"given":"B.","family":"Y\u00fcce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"G\u00fclberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Diebold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.L.","family":"Gerbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhep.2005.08.002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-8278%2899%2980297-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-200504000-00009"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F003655201300192076"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2002-30104"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1191%2F1352458504ms1007oa"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94524","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:32:36Z","timestamp":1745461956000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000094524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":6,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2006,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000094524","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}