{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:14:09Z","timestamp":1791101649835,"version":"4.1.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aim:&lt;\/i&gt; Parallel investigation, in a matched case-control study, of the association of different first-trimester markers with the risk of subsequent pre-eclampsia (PE). &lt;i&gt;Method:&lt;\/i&gt; The levels of different first trimester serum markers and fetal nuchal translucency thickness were compared between 52 cases of PE and 104 control women by non-parametric two-group comparisons and by calculating matched odds ratios. &lt;i&gt;Results:&lt;\/i&gt; In univariable analysis increased concentrations of inhibin A and activin A were associated with subsequent PE (p &lt; 0.02). Multivariable conditional logistic regression models revealed an association between increased risk of PE and increased inhibin A and translucency thickness and respectively reduced pregnancy-associated plasma protein A (PAPP-A) and placental lactogen . However, these associations varied with the gestational age at sample collection. For blood samples taken in pregnancy weeks 12 and 13 only, increased levels of activin A, inhibin A and nuchal translucency thickness, and lower levels of placenta growth factor and PAPP-A were associated with an increased risk of PE. &lt;i&gt;Conclusions:&lt;\/i&gt; Members of the inhibin family and to some extent PAPP-A and placental growth factor are superior to other serum markers, and the predicitive value of these depends on the gestational age at blood sampling. The availability of a single, early pregnancy \u2018miracle\u2019 serum marker for PE risk assessment seems unlikely in the near future.<\/jats:p>","DOI":"10.1159\/000094672","type":"journal-article","created":{"date-parts":[[2006,7,24]],"date-time":"2006-07-24T10:54:08Z","timestamp":1153738448000},"page":"15-21","source":"Crossref","is-referenced-by-count":36,"title":["First Trimester Markers for Pre-Eclampsia: Placental vs&lt;i&gt;.&lt;\/i&gt; Non-Placental Protein Serum Levels"],"prefix":"10.1159","volume":"63","author":[{"given":"Marcel","family":"Zwahlen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick A.","family":"Bersinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2899%2970239-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0301-2115%2896%2902647-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2896%2909264-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1081%2FPRG-120016794"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199902%2919%3A2%3C122%3A%3AAID-PD491%3E3.0.CO%3B2-R"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.87.4.1762"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0412.2004.00277.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2898%2970021-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2801%2901341-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2801%2901528-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000052943"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0029-7844%2896%2900179-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1081%2FPRG-120021059"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2F372425a0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm0997-1029"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2898%2970540-X"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-5456%2801%2900284-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2803%2900902-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0301-2115%2802%2900414-1"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.396"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.287.24.3183"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.282.22.2131"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1016674503298"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080%2F00016340500501715"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdeh767"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.placenta.2005.05.009"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94672","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:34:13Z","timestamp":1745462053000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000094672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,20]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000094672","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,20]]}}}