{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:57:43Z","timestamp":1745470663461,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Introduction:&lt;\/i&gt; The use of monoclonal antibodies against the \u03b1-chain of the membrane-bound interleukin-2 receptor (IL-2R\u03b1) as immune suppressants causes characteristic changes in the levels of soluble interleukin-2 receptor (sIL-2R) in serum and urine. &lt;i&gt;Methods:&lt;\/i&gt; 38 kidney transplant patients were included in this study. 28 of them received an induction therapy with the IL-2R antibody basiliximax (Simulect\u00ae) in addition to standard immunosuppression, 10 patients constituted the control group. &lt;i&gt;Results:&lt;\/i&gt; Time courses of sIL-2R levels of Simulect patients with and without complications after transplantation have been compared. It turned out that of a total of 18 cases with complications 15 cases could be identified by their elevated sIL-2R levels, which corresponds to a sensitivity of 83%. &lt;i&gt;Conclusion:&lt;\/i&gt; Acute rejection, CMV infection, extrarenal bacterial infection and pyelonephritis in the transplant all cause a significant increase of the sIL-2R level even after application of Simulect.<\/jats:p>","DOI":"10.1159\/000094815","type":"journal-article","created":{"date-parts":[[2006,10,10]],"date-time":"2006-10-10T15:18:07Z","timestamp":1160493487000},"page":"232-239","source":"Crossref","is-referenced-by-count":4,"title":["Is the Determination of the Soluble Interleukin-2 Receptor after Application of Interleukin-2 Receptor Antibodies Still Appropriate for Immunological Monitoring after Renal Transplantation?"],"prefix":"10.1159","volume":"77","author":[{"given":"Amir","family":"Hamza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kersten","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagen","family":"Loertzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Fornara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,10,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0009-8981%2801%2900525-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199306000-00029"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2008-1047655"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2FPL00002644"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0041-1345%2898%2900667-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00116.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199705270-00023"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1432-2277.1996.tb01688.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-0012.2004.00221.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00336599"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F01.TP.0000101702.73759.F3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0041-1345%2897%2900107-3"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94815","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:35:35Z","timestamp":1745462135000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000094815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2006,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000094815","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2006]]}}}