{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:22:49Z","timestamp":1789370569087,"version":"build-2803163510"},"reference-count":31,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>Delusions are commonly encountered symptoms in patients with Alzheimer\u2019s disease and may lead to significant morbidity. The purpose of this article is to review all clinical trials to date focusing on the management of delusions in patients with Alzheimer\u2019s disease to determine the level of evidence for treatment. To achieve this objective, Medline was searched using the key words delusions, dementia, Alzheimer\u2019s disease and psychosis. Three main categories of treatment were identified: atypical antipsychotics, cholinesterase inhibitors, and other miscellaneous treatments. It was concluded that all forms of treatment were effective although the greatest burden of evidence existed for risperidone and donepezil. Side effects were noted in all forms of treatment and included somnolence and extrapyramidal effects for antipsychotic medications, whereas gastrointestinal effects were more prevalent in studies involving cholinesterase inhibitors. Further large scale, double-blind, randomized, controlled studies are required before a definitive conclusion can be reached. To our knowledge this is the only systematic review of this area.<\/jats:p>","DOI":"10.1159\/000094975","type":"journal-article","created":{"date-parts":[[2006,8,11]],"date-time":"2006-08-11T08:14:03Z","timestamp":1155284043000},"page":"260-266","source":"Crossref","is-referenced-by-count":11,"title":["Treatment of Delusions in Alzheimer\u2019s Disease \u2013 Response to Pharmacotherapy"],"prefix":"10.1159","volume":"22","author":[{"given":"Corinne","family":"Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radenka","family":"Bozanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana H.","family":"Atkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean B.","family":"Rourke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,8,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291099-1166%28200002%2915%3A2%3C99%3A%3AAID-GPS82%3E3.0.CO%3B2-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291099-1166%28199806%2913%3A6%3C410%3A%3AAID-GPS787%3E3.0.CO%3B2-S"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1017%2FS0033291700033420"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.248.3.333"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.930080906"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-3223%2899%2900059-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4088%2FJCP.v62n1110"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajp.157.7.1150"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4088%2FJCP.v60n0207"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.551"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2F1099-1166%28200112%2916%3A1%2B%3C%3A%3AAID-GPS569%3E3.0.CO%3B2-J"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchpsyc.57.10.968"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4088%2FJCP.v62n0108"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.1032"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00002093-200204000-00011"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000077367"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1517%2F14740338.3.5.425"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F00002826-200211000-00007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0167-4943%2801%2900187-X"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.318.7184.633"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajp.161.3.532"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1192%2Fbjp.140.2.149"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291099-1166%28199611%2911%3A11%3C965%3A%3AAID-GPS418%3E3.0.CO%3B2-M"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajp.162.9.1763-a"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1017%2FS1355617700677081"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.69.2.167"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.1991.00530180075020"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajp.157.5.708"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1001%2Farchpsyc.57.12.1165"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1017%2FS1041610200006657"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.294.15.1934"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94975","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:37:30Z","timestamp":1745462250000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000094975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000094975","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}