{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:10:06Z","timestamp":1745464206327,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Aim:&lt;\/i&gt; To investigate testicular torsion-induced changes on the electrical field stimulation (EFS)-induced contractions in rabbit vasa deferentia and to evaluate the effect of mexiletine. &lt;i&gt;Methods:&lt;\/i&gt; 18 male New Zealand albino rabbits were used in this experiment. Rabbits were divided into three groups: (1) control group (n = 6); (2) torsion group (n = 6), and (3) mexiletine group (n = 6). In the control group, vasa deferentia on both sides were harvested. In the torsion and mexiletine groups, the left testes of the rabbits were subjected to 720\u00b0 of clockwise torsion for 2 h and then detorsion was performed. In the mexiletine group, 50 mg\/kg i.p. mexiletine was administered 1 h before detorsion. Following 24 h of the torsion, vasa deferentia on both sides were harvested and 2-cm strips including both the prostatic and epididymal portions were prepared to record EFS-induced contractions. &lt;i&gt;Results:&lt;\/i&gt; Testicular torsion caused a significant inhibition in both phases of EFS-induced biphasic contractions of the ipsi- and contralateral vasa deferentia. Mexiletine treatment did not affect these inhibitory responses. Torsion\/detorsion of the spermatic cord did not alter exogenously applied noradrenaline-induced contractions in both vasa deferentia. However, KCl-induced contractions diminished significantly in ipsilateral vas deferens of the torsion group and mexiletine restored this inhibition. &lt;i&gt;Conclusions:&lt;\/i&gt; Unilateral testicular torsion\/detorsion leads to inhibition in both phases of EFS-induced biphasic contractions of the ipsi- and contralateral vasa deferentia by causing a defect in presynaptic nerve transmission. However, mexiletine has no effect on this inhibition. Inhibition of the KCl-induced contractions in the ipsilateral vas deferens, which indicates postsynaptic tissue damage, is restored by administering mexiletine 1 h prior to detorsion.<\/jats:p>","DOI":"10.1159\/000094980","type":"journal-article","created":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T09:44:50Z","timestamp":1155548690000},"page":"423-429","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Mexiletine on Electrical Field Stimulation-Induced Contractile Responses in the Ipsilateral and Contralateral Vasa Deferentia after Unilateral Testicular Torsion\/Detorsion"],"prefix":"10.1159","volume":"38","author":[{"given":"\u0130brahim Onur","family":"\u00d6zen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130smail Mert","family":"Vural","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Moral\u0131o\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fcreyya","family":"Barun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep Sevim","family":"Ercan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Sar\u0131o\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,9,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.1986.tb05916.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.1990.tb14715.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.1978.tb02764.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.1800751015"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410X.2003.04307.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-4547%2819991101%2958%3A3%3C442%3A%3AAID-JNR10%3E3.0.CO%3B2-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007010200023"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00005344-200412000-00003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2801%2902195-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1681.1998.tb02169.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00210-005-1073-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00701-003-0209-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1254%2Fjjp.81.7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2165%2F00003088-199937050-00002"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS1043-6618%2803%2900157-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2F47495"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1474-8673.1992.tb00390.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.lfs.2005.06.019"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0098-2997%2899%2900002-3"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00300075"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0891-5849%2803%2900467-2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.1989.tb05949.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.94.6.2724"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI115313"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94980","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/94980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:37:33Z","timestamp":1745462253000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000094980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000094980","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"type":"print","value":"0014-312X"},{"type":"electronic","value":"1421-9921"}],"subject":[],"published":{"date-parts":[[2006]]}}}