{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:08:22Z","timestamp":1791029302725,"version":"4.1.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The heat shock protein H11 is silenced in melanoma cell lines, where its forced expression by demethylation with Aza-C triggers apoptosis. &lt;i&gt;Objective:&lt;\/i&gt; To examine whether H11 is silenced by aberrant DNA methylation in melanoma as compared to nevi and normal skin tissues. &lt;i&gt;Methods:&lt;\/i&gt; Cell suspensions from benign intradermal nevi, atypical nevi and malignant melanoma tissues were used in reverse-transcriptase PCR and methylation-specific PCR. Paraffin-embedded tissues were stained with H11 antibody. &lt;i&gt;Results:&lt;\/i&gt; H11 is methylated in 60\u201375% of melanoma and atypical nevi, but not in normal skin or most benign nevi. Methylation is inversely correlated with H11 expression. &lt;i&gt;Conclusion:&lt;\/i&gt; The heat shock protein H11 is silenced by aberrant DNA methylation in melanoma, but not benign melanocytic lesions or normal skin melanocytes. The data suggest that H11 is a promising target for the molecular therapy of melanoma.<\/jats:p>","DOI":"10.1159\/000095035","type":"journal-article","created":{"date-parts":[[2006,10,10]],"date-time":"2006-10-10T15:18:07Z","timestamp":1160493487000},"page":"192-199","source":"Crossref","is-referenced-by-count":14,"title":["Aberrant DNA Methylation Silences the Novel Heat Shock Protein H11 in Melanoma but Not Benign Melanocytic Lesions"],"prefix":"10.1159","volume":"213","author":[{"given":"B.K.","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia C.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Laing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dakara A.","family":"Rucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Burnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Aurelian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,10,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2899%2970562-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.12.22.3467"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00008390-200108000-00009"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.det.2004.09.005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.20402"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1006%2Fexcr.1999.4455"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F92.19.1564"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.2001.5427"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M002140200"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2001.00191.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000044380.54893.4B"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1042%2FBJ20041314"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M303834200"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2741%2F1736"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12336800"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1998.02260.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.89.5.1827"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.93.18.9821"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1207111"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-437X%2801%2900259-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1042%2FBJ20041314"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-05-1183"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/95035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/95035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:37:50Z","timestamp":1745462270000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000095035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2006,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000095035","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}