{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:09:23Z","timestamp":1790132963798,"version":"4.0.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; People who are cognitively impaired not demented (CIND) can be at an increased risk for developing dementia, but little is known about the natural history of CIND in clinical settings. &lt;i&gt;Method:&lt;\/i&gt; We examined the 2-year outcome of CIND subjects in the Canadian Cohort Study of Cognitive Impairment and Related Dementias.CIND was diagnosed when at least one positive item was endorsed on the DSM-III-R dementia criteria, but not all criteria were met. CIND was further subclassified as: pre-Alzheimer\u2019s disease (pre-AD), vascular cognitive impairment (VCI-ND), non-AD degenerative, psychiatric, other neurologic, other medical conditions, mixed disorders and no etiology identified (not otherwise specified [NOS]). &lt;i&gt;Result:&lt;\/i&gt; Of 146 CIND patients with 2-year follow-up data available, 49 (34%) progressed to dementia, while 20 (14%) recovered to not cognitively impaired (NCI). Progressors were significantly older than stable CIND and reverters (p &lt; 0.0001; mean age = 71.1, 64.3, and 59.1, respectively), and there were significantly (p = 0.001) more ApoE &amp;#917;4 carriers among progressors (67%) than stable CIND (29%) and reverters (12%). Pre-AD CIND and VCI-ND had the highest rate of conversion to dementia (41.0 and 40.0%, respectively), while psychiatric CIND and CIND NOS had highest rate of recovery to NCI (20.0 and 30.0%, respectively). All conversions in pre-AD CIND were to \u2018probable AD\u2019. &lt;i&gt;Conclusion:&lt;\/i&gt; CIND consists of a heterogeneous group of disorders that can be classified syndromically. Many subclassess \u2013 not just those with pre-AD CIND \u2013 are at high risk of progression to dementia, usually to Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1159\/000095751","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T11:07:55Z","timestamp":1158059275000},"page":"413-420","source":"Crossref","is-referenced-by-count":40,"title":["Outcomes of Cognitively Impaired Not Demented at 2 Years in the Canadian Cohort Study of Cognitive Impairment and Related Dementias"],"prefix":"10.1159","volume":"22","author":[{"given":"Ging-Yuek R.","family":"Hsiung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Donald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Grand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi W.","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge G.","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Loy-English","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Kertesz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Rockwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard H.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,11,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.56.3.303"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.58.12.1985"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080%2F87565648609540348"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F87565648909540440"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1017%2FS1041610294001626"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2897%2901007-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.60.4.577"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000144281.38555.E3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000071189"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2796.2004.01388.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.34.7.939"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.57.4.416"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.47.5.1113"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1300%2FJ018v08n03_02"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5014%2Fajot.53.5.471"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.44.12.2308"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000132523.27540.81"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.57.9.1655"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000034176.07159.F8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000089238.07771.C7"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/95751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/95751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:45:27Z","timestamp":1745462727000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000095751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":20,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2006,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000095751","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}