{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:04:09Z","timestamp":1789459449657,"version":"build-2803163510"},"reference-count":23,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Cardiovascular disease (CVD) is the leading cause of mortality in hemodialysis (HD). An elevated incidence of cardiovascular calcifications (CVC) is observed in HD. Fetuin-A is an important inhibitor of CVC. Reduced fetuin-A levels associate with inflammation and increased cardiovascular (CV) mortality in HD. In this study we investigated the association of fetuin-A levels and CVC. &lt;i&gt;Method:&lt;\/i&gt; We evaluated a cohort of 115 patients (67 males), aged 63 \u00b1 16 years with a HD vintage \u22679 months. Presence of CVC was assessed by ultrasound imaging of the abdominal aorta, common carotid arteries, bilateral ilio-femoral axis, aortic and mitral cardiac valves. The presence of CVC was analyzed as a CVC score (CVCS) (0\u20137) according to the number of CVC sites. Patients were arbitrary stratified in three groups: group I (CVCS = 0), group II (0 &lt; CVCS &lt; 6) and group III (CVCS \u2267 6). Patients without CVC were younger, non-diabetic and with a negative history for CV events. &lt;i&gt;Results:&lt;\/i&gt; Patients with evidence of CVC in more than 5 sites had lower serum fetuin-A levels (0.41 \u00b1 0.22 g\/l) compared to patients with CVCS = 0 (0.51 \u00b1 0.17 g\/l, p = 0.048). In addition a worse CVCS was associated with higher serum levels of C-reactive protein (p = 0.002) and fibrinogen (p &lt; 0.001). Serum fetuin-A levels lower than 0.290 g\/l were associated with higher risk of a worse CVCS, independently from traditional risk factors. &lt;i&gt;Conclusion:&lt;\/i&gt; Chronic inflammation in HD patients leads to lower serum fetuin-A levels. The present study confirms the independent and significant association between reduced serum fetuin-A levels and multi-site CVC in HD.<\/jats:p>","DOI":"10.1159\/000095782","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T11:07:55Z","timestamp":1158059275000},"page":"423-429","source":"Crossref","is-referenced-by-count":53,"title":["Serum Fetuin-A Levels Link Inflammation and Cardiovascular Calcification in Hemodialysis Patients"],"prefix":"10.1159","volume":"26","author":[{"given":"Mario","family":"Cozzolino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Galassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Biondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Turri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Papagni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Mongelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Civita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Gallieni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Brancaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080902"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000019641.41496.1E"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000081664.65772.EB"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F15.7.1014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.99.18.2434"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2Fhy1001.096358"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000145894.57533.C4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00421.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.271.34.20789"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI200317202"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2803%2912710-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00273.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00455.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.semnephrol.2005.05.002"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2005.09.014"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00333.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00172.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00345.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfk045"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200005183422003"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI109551"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI108932"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfg486"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/95782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/95782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:45:56Z","timestamp":1745462756000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000095782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000095782","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}