{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T02:56:48Z","timestamp":1769223408001,"version":"3.49.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T00:00:00Z","timestamp":1158796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T00:00:00Z","timestamp":1158796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Beckwith-Wiedemann syndrome (BWS) is a distinct clinical syndrome with unique features, generally diagnosed postnatally. &lt;i&gt;Case:&lt;\/i&gt; A 26-year-old patient, gravida 4, para 3-0-0-3, was noted to have an abnormal maternal serum screen. Amniocentesis with imaging studies were remarkable only for a two-vessel umbilical cord and prominent maternal ovaries. The patient developed HELLP syndrome at 28 weeks and delivered a viable female infant with distinct clinical features. The diagnosis of BWS was confirmed by hypermethylation of the &lt;i&gt;H19&lt;\/i&gt; gene on chromosome 11p15.5. &lt;i&gt;Conclusion:&lt;\/i&gt; This case describes a novel presentation of BWS and underscores the diagnostic potential of routine prenatal screens.<\/jats:p>","DOI":"10.1159\/000095837","type":"journal-article","created":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T08:38:34Z","timestamp":1158914314000},"page":"18-22","source":"Crossref","is-referenced-by-count":18,"title":["Beckwith-Wiedemann Syndrome Presenting with an Elevated Triple Screen in the Second Trimester of Pregnancy"],"prefix":"10.1159","volume":"22","author":[{"given":"Kjersti M.","family":"Aagaard-Tillery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Buchbinder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew P.","family":"Boente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk D.","family":"Ramin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2000.106217"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fjcu.10017"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.10143"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000264296"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1067%2FS0022-3476%2803%2900306-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2559.2001.01256.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0143-4004%2897%2990012-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199703%2917%3A3%3C276%3A%3AAID-PD52%3E3.0.CO%3B2-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000263943"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1515%2Fjpme.1989.17.5.351"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.1320240117"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8628%2819960315%2962%3A2%3C145%3A%3AAID-AJMG6%3E3.0.CO%3B2-V"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0223%28200006%2920%3A6%3C511%3A%3AAID-PD849%3E3.0.CO%3B2-B"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0028-2243%2889%2990045-2"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/95837","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/95837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:46:35Z","timestamp":1745462795000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000095837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,21]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000095837","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,21]]}}}