{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:58:16Z","timestamp":1745470696523,"version":"3.40.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T00:00:00Z","timestamp":1158883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T00:00:00Z","timestamp":1158883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; Facilitate risk assessment of vital complications in fetuses of pregnancies affected by acute parvovirus B19 (B19V) infection. &lt;i&gt;Design:&lt;\/i&gt; Study of the natural course of maternal B19V infection in four cases, from early pregnancy on. &lt;i&gt;Setting:&lt;\/i&gt; University Medical Center in the Netherlands. &lt;i&gt;Population:&lt;\/i&gt; Pregnant mothers attending obstetric services. &lt;i&gt;Methods:&lt;\/i&gt; Serial measurements of the maternal and fetal or neonatal viral load and antibody responses. &lt;i&gt;Main Outcome Measures:&lt;\/i&gt; Maternal and fetal\/neonatal serum B19V viral DNA load and specific IgM and IgG antibodies in maternal serum. &lt;i&gt;Results:&lt;\/i&gt; Peak viral load levels occurred within 1 week after maternal infection and peak IgM levels were observed 1 week after the peak viral load levels. Approximation of IgG and IgM ratios usually took place 4 weeks after infection. Vertical transmission occurred 1\u20133 weeks after maternal infection, suggesting that fetal infection occurs during the maternal peak viral load. &lt;i&gt;Conclusions:&lt;\/i&gt; Maternal B19V DNA load levels and IgM responses are useful to estimate the risk of parvovirus B19-associated fetal complications. The maternal peak viral load directly precedes the onset of fetal infection and may be used to indicate the stage of intrauterine B19V infection.<\/jats:p>","DOI":"10.1159\/000095845","type":"journal-article","created":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T08:38:34Z","timestamp":1158914314000},"page":"55-62","source":"Crossref","is-referenced-by-count":19,"title":["Parvovirus B19 Infection in Pregnancy Studied by Maternal Viral Load and Immune Responses"],"prefix":"10.1159","volume":"22","author":[{"given":"Timo R.","family":"de Haan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias F.C.","family":"Beersma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric C.J.","family":"Claas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"Oepkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aloys C.M.","family":"Kroes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans J.","family":"Walther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01311158"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1099%2Fjmm.0.05485-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra030840"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0163-4453%2898%2990346-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fpd.940"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1086%2F342575"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.2001.00471.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2001.116690"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053%2Fplac.1998.0353"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02771838"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.20049"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0223%28199912%2919%3A12%3C1119%3A%3AAID-PD716%3E3.0.CO%3B2-X"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080%2F107710498174182"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS1386-6532%2802%2900021-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.42.5.2013-2019.2004"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fjmv.2216"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijid.2003.09.004"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080%2F713605925"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1128%2FCMR.15.3.485-505.2002"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2897%2900575-9"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1423-0410.2002.00132.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jcv.2005.04.005"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200001063420102"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1067%2Fmob.2002.128024"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jcv.2005.11.002"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1128%2FCDLI.8.2.288-292.2001"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-9071%28199802%2954%3A2%3C140%3A%3AAID-JMV12%3E3.0.CO%3B2-N"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/95845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/95845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:46:42Z","timestamp":1745462802000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000095845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,22]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000095845","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2006,9,22]]}}}