{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:32:51Z","timestamp":1791091971708,"version":"4.1.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,10,2]],"date-time":"2006-10-02T00:00:00Z","timestamp":1159747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,10,2]],"date-time":"2006-10-02T00:00:00Z","timestamp":1159747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> Subcutaneous immunotherapy for respiratory allergy has shown a long lasting efficacy after its discontinuation, whereas evidence in the case of sublingual immunotherapy (SLIT) is weak. This retrospective study evaluates whether SLIT exerts a long-lasting effect and whether it relates to its duration. <i>Methods:<\/i> Sixty-five patients allergic to mite and positive to methacholine challenge 13 years ago were studied. Twelve (control group, SLIT 0) were treated for 4 years only with standard pharmacological therapy (SPT), while 53 received SLIT and SPT. Among these, four groups were identified according to SLIT duration. Fifteen patients were treated for 1 year (SLIT 1), 10 for 2 (SLIT 2), 14 for 3 (SLIT 3) and 14 for 4 years (SLIT 4). Clinical parameters (symptom monthly score, SMS), bronchial reactivity and FEV<sub>1<\/sub> were evaluated in 1992 (run-in), 1993 (baseline) and every 2 years from 1997 to 2005. <i>Results:<\/i> Two to 3 years after the treatment ended, a positive effect on SMS, but not methacholine challenge and FEV<sub>1<\/sub>, was seen in the SLIT groups versus SLIT 0. At this time interval an effect on methacholine challenge was also seen in SLIT 3. After 7\u20138 years a significant difference was seen for SMS, i.e., it was significantly better in SLIT 4 than in the other groups, while bronchial reactivity was still improved in SLIT 1, 3 and 4 only after 5\u20136 years. <i>Conclusions:<\/i>The effects of a 4-year SLIT on clinical parameters but not bronchial reactivity and FEV<sub>1<\/sub> last 7\u20138 years after its discontinuation. SLIT shorter than 4 years yields proportionally less impressive results.<\/jats:p>","DOI":"10.1159\/000096001","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T06:09:01Z","timestamp":1160028541000},"page":"70-78","source":"Crossref","is-referenced-by-count":51,"title":["Long-Lasting Effects of Sublingual Immunotherapy for House Dust Mites in Allergic Rhinitis with Bronchial Hyperreactivity: A Long-Term (13-Year) Retrospective Study in Real Life"],"prefix":"10.1159","volume":"142","author":[{"given":"Maurizio","family":"Marogna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Massolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Falagiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,10,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2003.11.025"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1988.tb01631.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2002.1o3264.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.1999.00900.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1997.tb01251.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2897%2970240-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2000.00191.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1996.tb00155.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2895%2970223-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2001.118891"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1994.tb02273.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.1999.00203.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2000.00495.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2000.00655.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000070926"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.06.058"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000024322"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.1999.00267.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2001.00181.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2004.00616.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.03.013"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2004.00508.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1398-9995.2003.00387.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.2003.01622.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-3038.2003.00025.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.07.012"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199908123410702"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1996.tb00003.x"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:48:05Z","timestamp":1745462885000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000096001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,2]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000096001","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,2]]}}}