{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:06:46Z","timestamp":1761894406012,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Aim:&lt;\/i&gt; To evaluate the most important factors correlated with survival in patients with endocrine tumors of the ileum, both at the time of diagnosis and during the follow-up period. &lt;i&gt;Methods:&lt;\/i&gt; Fifty-nine patients with ileal endocrine tumors diagnosed in our institution between 1990 and 2004 were studied. &lt;i&gt;Results:&lt;\/i&gt; The study included 36 men (61%) and 23 women (39%). The median age of the patients at the time of diagnosis was 61.4 (range 18\u201383) years. The median follow-up period was 71.9 (range 5\u2013287) months. Forty patients (67.8%) were still alive at the end of the study; the median survival time was 172 months, and the 5-year survival rate was 78.9%. By univariate analysis, the survival rate was significantly related to female sex (p = 0.024) and flushing alone (p = 0.028) and associated with diarrhea at diagnosis (p = 0.015), weight loss at diagnosis (p = 0.038), Ki-67 level (p = 0.025), stage of disease at diagnosis (p = 0.012), presence of liver metastases at follow-up (p = 0.005), presence of diffuse metastases at diagnosis (p = 0.005) and at follow-up (p = 0.007), and type of surgical approach (overall: p = 0.018; not operated vs. radical surgery: p = 0.008; not operated vs. palliative surgery: p = 0.045). Using multivariate analysis, only female gender (p = 0.012) and the presence of liver metastases at follow-up (p = 0.004) were significantly related to survival. &lt;i&gt;Conclusion:&lt;\/i&gt; In the present study, female gender and the appearance of liver metastases at follow-up seem to be the main conditions which determine the poor prognosis of patients with ileal endocrine tumors.<\/jats:p>","DOI":"10.1159\/000096053","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T16:36:21Z","timestamp":1162485381000},"page":"380-386","source":"Crossref","is-referenced-by-count":33,"title":["Endocrine Tumors of the Ileum: Factors Correlated with Survival"],"prefix":"10.1159","volume":"83","author":[{"given":"Paola","family":"Tomassetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Campana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Piscitelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Casadei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Nori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Brocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Santini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Pezzilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Corinaldesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2005.03.038"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.11105"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.2003.026401"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000080731"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002680010236"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00268-002-6630-z"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1677%2Ferc.1.01017"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819970315%2979%3A6%3C1086%3A%3AAID-CNCR5%3E3.0.CO%3B2-E"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-199906000-00008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00268-003-7019-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00268-004-7610-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fjso.20179"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-1068-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0007-1323.2001.01798.x"}],"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:48:39Z","timestamp":1745462919000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000096053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":14,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2006,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000096053","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"type":"print","value":"0028-3835"},{"type":"electronic","value":"1423-0194"}],"subject":[],"published":{"date-parts":[[2006]]}}}