{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:13Z","timestamp":1787017873576,"version":"build-2736575974"},"reference-count":14,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The calcipotriol\/betamethasone dipropionate two-compound product is safe and effective in the short-term treatment of psoriasis. &lt;i&gt;Objective:&lt;\/i&gt; The primary objective was to investigate the safety of two treatment regimens involving use of the two-compound product over 52 weeks. The efficacy results are presented here. &lt;i&gt;Methods:&lt;\/i&gt; Six hundred and thirty-four patients were randomised double-blind to treatment (once daily, when required) with either: 52 weeks of two-compound product (two-compound group), 52 weeks of alternating 4-week periods of two-compound product and calcipotriol (alternating group), or 4 weeks of two-compound product followed by 48 weeks of calcipotriol (calcipotriol group). &lt;i&gt;Results:&lt;\/i&gt; There was a trend towards a difference between treatments from the overall treatment effect for the percentage of satisfactory responses for each patient during the study (p = 0.071). This appeared to be due to the comparison of the two-compound and calcipotriol groups (p = 0.025). &lt;i&gt;Conclusion:&lt;\/i&gt; There was a trend towards the efficacy of the two-compound product used for up to 52 weeks being better than that of 4 weeks of the two-compound product followed by 48 weeks of calcipotriol.<\/jats:p>","DOI":"10.1159\/000096069","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T12:37:54Z","timestamp":1164803874000},"page":"319-326","source":"Crossref","is-referenced-by-count":63,"title":["Efficacy Results of a 52-Week, Randomised, Double-Blind, Safety Study of a Calcipotriol\/Betamethasone Dipropionate Two-Compound Product (Daivobet\u00ae\/Dovobet\u00ae\/Taclonex\u00ae) in the Treatment of Psoriasis Vulgaris"],"prefix":"10.1159","volume":"213","author":[{"given":"K.","family":"Kragballe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Austad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bibby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"de la Brassinne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cambazard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Heikkil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Peyri Rey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5.","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Toole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Wozel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,12,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199503023320907"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2899%2970112-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000066440"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2003.130"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080%2F00015550252948194"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2004.05986.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2710.2000.00254.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000246851"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109%2F09546639309089517"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2006.07236.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000247698"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.123.10.1308"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2003.08.003"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000086444"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:48:46Z","timestamp":1745448526000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000096069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000096069","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}