{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:46:49Z","timestamp":1759333609578,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T00:00:00Z","timestamp":1160524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T00:00:00Z","timestamp":1160524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol Physiol"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Near-infrared reflectance confocal microscopy (RCM) is a noninvasive tool that provides real-time images of thin virtual horizontal tissue sections. &lt;i&gt;Aims\/Methods:&lt;\/i&gt; We have used a rhino mouse model in combination with topical application of all-trans-retinoic acid and all-trans-retinol to investigate the usefulness of RCM as a noninvasive imaging tool to evaluate comedolysis in vivo and over time. Optical images were correlated with routine histology. &lt;i&gt;Results:&lt;\/i&gt; Our results demonstrate that RCM in vivo can visualize the process of transformation of utriculi (pseudocomedones) towards a normal-appearing follicular structure during retinoid treatment. The retinoic acid intervention group showed a dose-related response, while the vehicle-treated group did not show utricular changes. &lt;i&gt;Conclusions:&lt;\/i&gt; RCM represents a useful tool for in vivo morphological and quantitative evaluation of skin utriculi over time and could be used as an adjunct tool to histopathological techniques for comedolysis studies.<\/jats:p>","DOI":"10.1159\/000096169","type":"journal-article","created":{"date-parts":[[2006,10,12]],"date-time":"2006-10-12T06:44:10Z","timestamp":1160635450000},"page":"29-36","source":"Crossref","is-referenced-by-count":15,"title":["Real-TimeReflectance Confocal Microscopy, a Noninvasive Tool for in vivo Quantitative Evaluation of Comedolysis in the Rhino Mouse Model"],"prefix":"10.1159","volume":"20","author":[{"given":"K.","family":"Nakano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kiyokane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Benvenuto-Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,10,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clindermatol.2004.03.009"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Far.1091700409"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12550409"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12263280"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12261472"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1991.tb14766.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000210926"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000051376"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000211478"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2000.00025.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clindermatol.2004.03.008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12606215"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.1999.00690.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0022-202x.2001.01337.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2002.t01-1-17642.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0022-202X.2004.23562.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jid.5700055"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0560.1999.tb01829.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2899%2970151-9"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2001.117395"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2002.124690"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0022-202X.2004.23605.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0625.1994.tb00278.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0560.1998.tb01686.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0022-202X.2005.23786.x"}],"container-title":["Skin Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:50:00Z","timestamp":1745463000000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000096169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,11]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000096169","archive":["Portico"],"relation":{},"ISSN":["1660-5527","1660-5535"],"issn-type":[{"type":"print","value":"1660-5527"},{"type":"electronic","value":"1660-5535"}],"subject":[],"published":{"date-parts":[[2006,10,11]]}}}