{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:39:51Z","timestamp":1778564391580,"version":"3.51.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T00:00:00Z","timestamp":1160524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T00:00:00Z","timestamp":1160524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol Physiol"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Anti-inflammatory and skin hydration properties of a dietary supplement and 2 topical formulations (Anthogenol\u00ae) with oligomeric proanthocyanidins were investigated. &lt;i&gt;Methods:&lt;\/i&gt; Forty-two subjects were randomized into 2 groups: one taking the dietary supplement (100 mg\/day) and the other without supplement. After 4 weeks, erythema was induced using UV radiation followed by treatment with topical cream or lotion. Erythema was measured for up to 72 h after irradiation. Skin hydration after 1 and 2 weeks of application of the cream and lotion was also measured in separate test fields. &lt;i&gt;Results:&lt;\/i&gt; Both topical formulations led to a significant suppression of erythema formation and the dietary supplement led to an additional slightly stronger suppression. Thus 72 h after UV exposure and compared to the control fields of patients that had not taken a dietary supplement, erythema was slightly (13.2%) lower in the subjects that had taken a dietary supplement. The cream resulted in a maximal reduction of erythema of 45.9% (p = 0.0015), while the lotion resulted in a maximal reduction of 53.1% (p = 0.0002). Both topical formulations also increased skin hydration (by nearly 20%; p &lt; 0.002 for all combinations of dietary supplementation and topical treatment) and the hydration was higher in the group taking the dietary supplement. &lt;i&gt;Conclusion:&lt;\/i&gt; The regular use of Anthogenol\u00ae products may help to protect from free-radical-mediated skin inflammation and to increase skin hydration.<\/jats:p>","DOI":"10.1159\/000096171","type":"journal-article","created":{"date-parts":[[2006,10,12]],"date-time":"2006-10-12T06:44:10Z","timestamp":1160635450000},"page":"43-49","source":"Crossref","is-referenced-by-count":24,"title":["Anti-Inflammatory and Skin-Hydrating Properties of a Dietary Supplement and Topical Formulations Containing Oligomeric Proanthocyanidins"],"prefix":"10.1159","volume":"20","author":[{"given":"B.","family":"Hughes-Formella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Wunderlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,10,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000080215"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000088014"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-3623%2897%2900332-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2F20.9.1737"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.phytochem.2005.03.025"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2Fbgg095"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-2952%2884%2990004-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-8137.2004.01217.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0022-202X.2004.23560.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0891-5849%2800%2900445-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2F22.2.287"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0022-202X.2003.22133.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1998.02447.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000018064"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000049400"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000017904"}],"container-title":["Skin Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:50:01Z","timestamp":1745463001000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000096171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,11]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000096171","archive":["Portico"],"relation":{},"ISSN":["1660-5527","1660-5535"],"issn-type":[{"value":"1660-5527","type":"print"},{"value":"1660-5535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,11]]}}}