{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:28:53Z","timestamp":1760707733480,"version":"3.40.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2006]]},"abstract":"<i>Background\/Aims:<\/i> Vitamin C levels decrease during hemodialysis (HD), which deteriorates antioxidant defense. Vitamin C may also act pro-oxidatively, via reduction in Fe(III). We sought to determine whether intravenous iron (Fe<sub>iv<\/sub>)-induced oxidative stress differs in HD patients with low and physiological vitamin C levels and whether intravenous vitamin C (C<sub>iv<\/sub>) administration during HD would change the response to Fe<sub>iv<\/sub>. <i>Patients and Methods:<\/i> Twenty patients with vitamin C deficiency (median 15.7 \u00b5mol\/l, range 8.0\u201322.7) received Fe<sub>iv<\/sub> (100 mg iron sucrose between 150 and 180 min of HD). After 4 weeks of oral supplementation, the levels of vitamin C were comparable with those of controls (60.1 \u00b5mol\/l, range 47.4\u201370.9). Patients were subsequently treated with (1) Fe<sub>iv<\/sub>, (2) Fe<sub>iv<\/sub> and continuous 2 mg\/min C<sub>iv<\/sub> throughout HD, (3) saline (S), and (4) S+C<sub>iv<\/sub>. Plasma thiobarbituric acid reacting substances (TBARS) and vitamin C were assessed before, during and after FE<sub>iv<\/sub>(S), and 15, 30 and 60 min after infusion. <i>Results:<\/i> Fe<sub>iv<\/sub> induced a comparable rise in TBARS in patients with vitamin C deficiency (before Fe<sub>iv<\/sub>, 1.9 \u00b5mol\/l, range 1.4\u20131.9; after Fe<sub>iv<\/sub>, 2.6 \u00b5mol\/l, range 2.3\u20132.9; p < 0.01) and in those with normal vitamin C (before Fe<sub>iv<\/sub>, 1.9 \u00b5mol\/l, range 1.7\u20132.1; after Fe<sub>iv<\/sub>, 2.6 \u00b5mol\/l, range 2.5\u20132.9; p < 0.01). Fe<sub>iv<\/sub>+C<sub>iv<\/sub> resulted in a greater increase in TBARS (after Fe<sub>iv<\/sub>, 3.1 \u00b5mol\/l, range 2.8\u20133.2) compared with Fe<sub>iv<\/sub> (p < 0.01). <i>Conclusion:<\/i> Iron sucrose-induced oxidative stress is comparable in HD patients with vitamin C deficiency and in those with normal vitamin C. We documented a pro-oxidative effect of vitamin C during Fe<sub>iv<\/sub>+C<sub>iv<\/sub> administration.<\/jats:p>","DOI":"10.1159\/000096474","type":"journal-article","created":{"date-parts":[[2006,10,23]],"date-time":"2006-10-23T14:07:10Z","timestamp":1161612430000},"page":"531-537","source":"Crossref","is-referenced-by-count":15,"title":["The Effect of Intravenous Iron on Oxidative Stress in Hemodialysis Patients at Various Levels of Vitamin C"],"prefix":"10.1159","volume":"24","author":[{"given":"Jarom\u00edr","family":"Eiselt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslav","family":"Racek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Opatrn\u00fd Jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladislav","family":"Trefil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Stehl\u00edk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,12,21]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1016%2FS0272-6386%2800%2970294-0"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1053%2Fj.ajkd.2005.06.018"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1023%2FB%3AUROL.0000022951.17591.0b"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1016%2F0076-6879%2890%2986093-B"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1053%2Fajkd.2002.33917"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1093%2Fndt%2Fgfg074"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1159%2F000070991"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1159%2F000014418"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1515%2FCCLM.1999.086"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1016%2F0891-5849%2895%2902043-8"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1046%2Fj.1523-1755.2003.00125.x"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1093%2Fndt%2F14.11.2680"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1093%2Fndt%2Fgfh928"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1016%2FS0272-6386%2803%2900419-0"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1074%2Fjbc.272.25.15656"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1006%2Fbbrc.2000.3711"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1081%2FJDI-200049533"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1046%2Fj.1523-1755.2003.00852.x"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1111%2Fj.1440-1797.2005.00424.x"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1053%2Fj.ajkd.2005.12.025"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1046%2Fj.1525-1594.2001.025006430.x"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1038%2Fsj.ki.5000109"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1093%2Fndt%2Fgfh928"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1093%2Fndt%2Fgfg579"},{"doi-asserted-by":"publisher","key":"ref25","DOI":"10.1111%2Fj.1523-1755.2005.00183.x"},{"doi-asserted-by":"publisher","key":"ref26","DOI":"10.1046%2Fj.1365-2362.2002.0320s1042.x"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96474","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:53:19Z","timestamp":1745463199000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000096474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":26,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000096474","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"type":"print","value":"0253-5068"},{"type":"electronic","value":"1421-9735"}],"subject":[],"published":{"date-parts":[[2006]]}}}