{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:11:15Z","timestamp":1792300275011,"version":"4.4.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T00:00:00Z","timestamp":1161907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T00:00:00Z","timestamp":1161907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Objective:<\/i> To test the hypothesis that metabolic syndrome predicts cognitive impairment, and to examine the association of single metabolic risk factors with cognitive functioning. <i>Methods:<\/i> Weperformed a 12-year follow-up study in a population-based sample of 101 women aged 60\u201370 years at baseline. Metabolic syndrome wasdefined by the National Cholesterol Education Program criteria (\u22673 out of 5 risk factors). Global cognitive function was measured by the Mini-Mental State Examination both at baseline and follow-up. A detailed neuropsychological evaluation for memory and cognitive speed was performed at follow-up. <i>Results:<\/i> The prevalence of metabolic syndrome increased from 13% at baseline to 49% at follow-up (p < 0.001). Women with metabolic syndrome at baseline had a 4.27 (95% confidence interval: 1.02\u201317.90; p = 0.047) times higher risk of poor memory at follow-up after adjustment for age, education and depression. The increasing number of metabolic risk factors was associated with worsening of memory at follow-up (p = 0.034 for linear trend). Women with low baseline levels of high-density lipoprotein (HDL) cholesterol were more likely to have poor memory at follow-up than those with higher HDL levels (p = 0.028). The risk of having poor memory increased by 46.5% (95% confidence interval: 15\u201366%; p = 0.008) with 1 SD decrease in HDL cholesterol level. <i>Conclusion:<\/i> In elderly women, metabolic syndrome may be an important contributor to worsening of memory, which is an essential part of mild cognitive impairment.<\/jats:p>","DOI":"10.1159\/000096636","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T10:10:49Z","timestamp":1161943849000},"page":"29-34","source":"Crossref","is-referenced-by-count":119,"title":["Metabolic Syndrome and Cognitive Function: A Population-Based Follow-Up Study in Elderly Women"],"prefix":"10.1159","volume":"23","author":[{"given":"Pirjo","family":"Komulainen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo A.","family":"Lakka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miia","family":"Kivipelto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maija","family":"Hassinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eeva-Liisa","family":"Helkala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irja","family":"Haapala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aulikki","family":"Nissinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Rauramaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2006,10,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2806%2968542-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.287.3.356"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.62.10.noc50112"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2804%2900681-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.53.9.1937"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.322.7300.1447"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2896%2990608-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.292.18.2237"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fije%2F23.3.495"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.285.19.2486"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000017049"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080%2F03610739708254029"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1037%2F0882-7974.12.3.479"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1037%2Fh0054651"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Farchpsyc.1965.01720310065008"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fageing%2Fafi027"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20289"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.294.5545.1354"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.2000.2372"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1080%2F07853890500401234"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.2002.tb04821.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.160.2.174"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.37977.495729.EE"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:55:11Z","timestamp":1745463311000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000096636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,27]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000096636","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,27]]}}}