{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:58:41Z","timestamp":1745470721961,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T00:00:00Z","timestamp":1162857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T00:00:00Z","timestamp":1162857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>Amiodarone, a highly effective medication for suppressing cardiac rhythm disturbances, may cause pulmonary injury, such as chronic interstitial lung diseases, in 5\u201315% of the patients who take it. We applied induced sputum (IS), a non-invasive technique, for diagnosing amiodarone-induced pulmonary toxicity. Four patients with interstitial lung disease who were treated by amiodarone for ischemic heart diseases were evaluated by a conventional clinical workup. All four patients showed marked interstitial pattern on computerized tomography and decreased diffusion capacity (DLCO-SB 51\u201376%). IS showed lymphocytosis, a high CD4 or CD8 count, eosinophilia and amiodarone in 3 of 4 patients. IS may be a useful tool for assessing amiodarone toxicity in patients with ischemic heart diseases and concomitant pulmonary side effects.<\/jats:p>","DOI":"10.1159\/000096782","type":"journal-article","created":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T10:54:41Z","timestamp":1162983281000},"page":"223-227","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Induced Sputum in Amiodarone-Associated Interstitial Lung Diseases"],"prefix":"10.1159","volume":"108","author":[{"given":"Elizabeth","family":"Fireman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Topilsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami","family":"Viskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel E.","family":"Priel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,11,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0735-1097%2888%2990321-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2800%2900864-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS1092-9134%2897%2980008-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00000441-199212000-00004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.47.1.25"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.1994.tb00990.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.86.4.541"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs003300000809"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.51.6.614"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2889%2990382-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.1994.tb02725.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2894%2990154-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.99.13348299"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.115.6.1720"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0954-6111%2899%2990269-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.120.1.275"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:56:33Z","timestamp":1745463393000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000096782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,7]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000096782","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"type":"print","value":"0008-6312"},{"type":"electronic","value":"1421-9751"}],"subject":[],"published":{"date-parts":[[2006,11,7]]}}}