{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:25Z","timestamp":1760188825410,"version":"3.40.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T00:00:00Z","timestamp":1166745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T00:00:00Z","timestamp":1166745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Scleromyxedema is an unusual skin disease characterized by mucinous infiltration of the skin. There is no satisfactory treatment for this disorder. &lt;i&gt;Case Report:&lt;\/i&gt; We report 2 cases of scleromyxedema, both associated with an IgG-\u03bb paraprotein. Treatment with thalidomide was started and great improvement of the lesion was noted as shown by a quality of life questionnaire similar to those used in rheumatoid arthritis. TNF-\u03b1 value was elevated in both cases during this treatment. &lt;i&gt;Discussion:&lt;\/i&gt; We hypothesize that the efficiency of thalidomide could be mediated by its costimulatory effect on T cytotoxic lymphocytes.<\/jats:p>","DOI":"10.1159\/000096914","type":"journal-article","created":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T23:18:32Z","timestamp":1166829512000},"page":"58-60","source":"Crossref","is-referenced-by-count":25,"title":["Scleromyxedema: Successful Treatment with Thalidomide in Two Patients"],"prefix":"10.1159","volume":"214","author":[{"given":"Mona","family":"Amini-Adle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadege","family":"Thieulent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Dalle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Balme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2006,12,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.140.3.277"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2004.01.058"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199705223362103"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2902197-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.187.11.1885"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000076491"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:58:06Z","timestamp":1745463486000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000096914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,22]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000096914","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2006,12,22]]}}}